(3S)-1-(carboxymethyl)-3-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-3,4,5,6-tetrahydro-<1>benzazocin-2-(1H)-one hydrochloride

Base Information

Chemical Name:(3S)-1-(carboxymethyl)-3-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-3,4,5,6-tetrahydro-<1>benzazocin-2-(1H)-one hydrochloride
CAS No.:97278-76-7
Molecular Formula:C₂₅H₃₀N₂O₅*ClH
Molecular Weight:474.985
Hs Code.:

Synonyms:(3S)-1-(carboxymethyl)-3-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-3,4,5,6-tetrahydro-<1>benzazocin-2-(1H)-one hydrochloride

Suppliers and Price of (3S)-1-(carboxymethyl)-3-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-3,4,5,6-tetrahydro-<1>benzazocin-2-(1H)-one hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S)-1-(carboxymethyl)-3-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-3,4,5,6-tetrahydro-<1>benzazocin-2-(1H)-one hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S)-1-(carboxymethyl)-3-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-3,4,5,6-tetrahydro-<1>benzazocin-2-(1H)-one hydrochloride

There total 6 articles about (3S)-1-(carboxymethyl)-3-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-3,4,5,6-tetrahydro-<1>benzazocin-2-(1H)-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 97278-74-5
(3S)-1-<(carbobenzyloxy)methyl>-3-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-3,4,5,6-tetrahydro-<1>-benzazocin-2(1H)-one

: 97278-76-7
(3S)-1-(carboxymethyl)-3-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-3,4,5,6-tetrahydro-<1>benzazocin-2-(1H)-one hydrochloride

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; under 760 Torr; Ambient temperature;
DOI:10.1021/jm00148a023

Reference yield:

: 22246-75-9
3,4,5,6-tetrahydro-1-benzazocin-2(1H)-one

: 97278-76-7
(3S)-1-(carboxymethyl)-3-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-3,4,5,6-tetrahydro-<1>benzazocin-2-(1H)-one hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 50 percent / PCl₅, Br₂, I₂ / CHCl₃ / 4 h / Heating

2: 83 percent / sodium azide / dimethylsulfoxide / 5 h / 60 °C

3: 57 percent / potassium tert-butoxide / tetrahydrofuran / 36 h / Ambient temperature

4: 9.2 g / di-n-butyltin dichloride / CHCl₃ / 24 h / Heating

5: 1.0 g / sodium cyanoborohydride / methanol; acetic acid / 18 h / Ambient temperature

6: 0.6 g / H₂ / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature

With sodium azide; phosphorus pentachloride; dibutyltin chloride; potassium tert-butylate; hydrogen; bromine; iodine; sodium cyanoborohydride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; chloroform; acetic acid; dimethyl sulfoxide;
DOI:10.1021/jm00148a023

Reference yield:

: 91167-28-1
3-bromo-3,4,5,6-tetrahydro-1-benzazocin-2(1H)-one

: 97278-76-7
(3S)-1-(carboxymethyl)-3-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-3,4,5,6-tetrahydro-<1>benzazocin-2-(1H)-one hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / sodium azide / dimethylsulfoxide / 5 h / 60 °C

2: 57 percent / potassium tert-butoxide / tetrahydrofuran / 36 h / Ambient temperature

3: 9.2 g / di-n-butyltin dichloride / CHCl₃ / 24 h / Heating

4: 1.0 g / sodium cyanoborohydride / methanol; acetic acid / 18 h / Ambient temperature

5: 0.6 g / H₂ / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature

With sodium azide; dibutyltin chloride; potassium tert-butylate; hydrogen; sodium cyanoborohydride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; chloroform; acetic acid; dimethyl sulfoxide;
DOI:10.1021/jm00148a023