22246-75-9

Usage

Type of Compound

Heterocyclic compound

Structure

Six-membered ring with a nitrogen atom

Classification

Cyclic amide

Derivative of

Benzazocine

Usage

Pharmaceutical research

Potential Applications

Development of new drugs for treating central nervous system disorders and other therapeutic targets

Research Areas

Medicinal chemistry and pharmacology

Properties

Promising candidate for drug discovery and development due to its structure and properties

Upstream product

• 187869-29-0 2,2-bis(phenylthio)-N-[o-(prop-2-enyl)phenyl]acetamide 

Downstream Products

• 7124-93-8 1,2,3,4,5,6-hexahydrobenzo[b]azocine 
• 103856-02-6 5-(2-aminophenyl)pentanoic acid hydrochloride 
• 97278-73-4 1-<(carbobenzyloxy)methyl>-3,4,5,6-tetrahydro-1-benzazocine-2,3(1H)-dione 
• 101386-38-3 (R)-2-[1-Ethoxycarbonylmethyl-2-oxo-1,4,5,6-tetrahydro-2H-benzo[b]azocin-(3E)-ylideneamino]-4-phenyl-butyric acid ethyl ester 
• 101386-40-7 (R)-2-[1-Benzyloxycarbonylmethyl-2-oxo-1,4,5,6-tetrahydro-2H-benzo[b]azocin-(3E)-ylideneamino]-4-phenyl-butyric acid ethyl ester 
• 97278-76-7 (3S)-1-(carboxymethyl)-3-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-3,4,5,6-tetrahydro-<1>benzazocin-2-(1H)-one hydrochloride 
• 97278-79-0 (3S)-1-(carboxymethyl)-3-<<(1S)-1-carboxy-3-phenylpropyl>amino>-3,4,5,6-tetrahydro-<1>benzazocin-2(1H)-one hydrochloride 
• 97278-79-0 (3S)-1-(carboxymethyl)-3-<<(1S)-1-carboxy-3-phenylpropyl>amino>-3,4,5,6-tetrahydro-<1>benzazocin-2(1H)-one hydrochloride 
• 97278-77-8 (3S)-1-(carbethoxymethyl)-3-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-3,4,5,6-tetrahydro-<1>benzazocin-2(1H)-one 
• 97278-78-9 (3R)-1-(carbethoxymethyl)-3-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-3,4,5,6-tetrahydro-<1>benzazocin-2(1H)-one 
• 97278-74-5 (3S)-1-<(carbobenzyloxy)methyl>-3-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-3,4,5,6-tetrahydro-<1>-benzazocin-2(1H)-one 
• 97278-75-6 (3R)-1-<(carbobenzyloxy)methyl>-3-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-3,4,5,6-tetrahydro-<1>-benzazocin-2(1H)-one 
• 85237-35-0 (E)-4-Phenyl-2,4,6-triaza-tricyclo[9.4.0.0^3,6]pentadeca-1⁽¹¹⁾,2,12,14-tetraen-5-one 
• 187869-69-8 3-Benzenesulfinyl-1-(4-methoxy-benzyl)-3,4,5,6-tetrahydro-1H-benzo[b]azocin-2-one 

Relevant academic research and scientific papers

Synthesis of tetrahydro-1-benzazocin-2(1H)-ones using 8-endo-trig radical cyclization of 2,2-bis-(phenylthio)-at-[o-(prop-2-enyl)-phenyl]acetamides

The effects of N-substituents upon the 8-endo-trig radical cyclization of 2,2-bis(phenylthio)-N-[o-(prop-2-enyl)phenyl]acetamides (4) were examined. The N-(p-methoxybenzyl) (4a) and N-tosyl derivatives (4b), when treated with tributyltin hydride in the presence of a small amount of azoisobutyronitrile, gave regioselectively the corresponding 3,4,5,6-tetrahydro-3-phenylthio-1-benzazocin2(1H)-ones (5a,b) (8-endo cyclization products) in 40 and 47% yields, respectively, while the N-unsubstituted derivative (4c) afforded the reduction products (6c) and (8) as the major products. Some chemical transformation reactions of 5a are also described.