2-(Pyridin-2-yl)quinoline-4-carboxylate

Base Information

• Chemical Name: 2-(Pyridin-2-yl)quinoline-4-carboxylate
• CAS No.: 57882-27-6
• Molecular Formula: C15H10 N2 O2
• Molecular Weight: 250.2521
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID40973481
• Wikidata: Q82957423
• Mol file: 57882-27-6.mol

Synonyms:2-(pyridin-2-yl)quinoline-4-carboxylate;DTXSID40973481;STK442811;AKOS005454193;CCG-256430;NCGC00339449-01;AB01117027-04

Chemical Property of 2-(Pyridin-2-yl)quinoline-4-carboxylate

Chemical Property:

• Appearance/Colour: tan solid
• Vapor Pressure: 1.03E-09mmHg at 25°C
• Boiling Point: 472 °C at 760 mmHg
• Flash Point: 239.2 °C
• PSA: 63.08000
• Density: 1.332 g/cm³
• LogP: 2.99500
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 249.066402534
• Heavy Atom Count: 19
• Complexity: 329

Purity/Quality:

99%, ^*data from raw suppliers

2-Pyridin-2-yl-quinoline-4-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=CC(=N2)C3=CC=CC=N3)C(=O)[O-]

Technology Process of 2-(Pyridin-2-yl)quinoline-4-carboxylate

There total 5 articles about 2-(Pyridin-2-yl)quinoline-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

sodium 2-(2-pyridinyl)-4-carboxyquinoline carboxylate → 2-(pyridin-2-yl)-quinoline-4-carboxylic acid (57882-27-6)

Guidance literature:

With hydrogenchloride; In water;

DOI:10.1080/00397919708006824

Reference yield: 89.0%

2-acetylpyridine (1122-62-9) + indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → 2-(pyridin-2-yl)-quinoline-4-carboxylic acid (57882-27-6)

Guidance literature:

indole-2,3-dione; With cetyltrimethylammonium hydroxide; In water; at 20 ℃; for 0.166667h; Sonication; Green chemistry;

2-acetylpyridine; In water; at 35 ℃; for 6.5h; Temperature; Sonication; Green chemistry;

DOI:10.1039/c7nj01937h

Reference yield:

2-acetylpyridine (1122-62-9) → 2-(pyridin-2-yl)-quinoline-4-carboxylic acid (57882-27-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / 33percent NaOH / 5 - 60 °C

2: 90 percent / 10percent HCl / H₂O

With hydrogenchloride; sodium hydroxide; In water;

DOI:10.1080/00397919708006824

upstream raw materials:

2-acetylpyridine

indole-2,3-dione

Downstream raw materials:

N-phenyl-2-(pyridin-2-yl)quinoline-4-carboxamide

2-pyridin-2-yl-quinoline-4-carboxylic acid [3-(benzhydrylidene-amino)-propyl]-methyl-amide

5-[5-(2-pyridyl)-4-azaphthalimido]isophthalic acid

5-[5-(2-pyridyl)-4-azaphthalimido]isophthaloyl dichloride

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