C₂₆H₃₄N₄O₂

Base Information

• Chemical Name: C₂₆H₃₄N₄O₂
• CAS No.: 1400928-22-4
• Molecular Formula: C₂₆H₃₄N₄O₂
• Molecular Weight: 434.582
• Mol file: 1400928-22-4.mol

Synonyms:C₂₆H₃₄N₄O₂

Chemical Property of C₂₆H₃₄N₄O₂

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of C₂₆H₃₄N₄O₂

There total 3 articles about C₂₆H₃₄N₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-acryloyl-N,N-dimethylindoline-(2RS)-2-carboxamide (1400928-15-5) + 1-phenylethyl piperazine (69628-75-7,759457-60-8) → C26H34N4O2 (1400928-22-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 60 ℃; for 36h; Inert atmosphere;

DOI:10.1016/j.ejmech.2012.07.021

Reference yield:

1-t-butoxycarbonyl-2,3-dihydroindole-2-carboxylic acid (137088-51-8,133851-52-2) → C26H34N4O2 (1400928-22-4)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

2: trifluoroacetic acid / tetrahydrofuran / 2.5 h / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4: triethylamine / tetrahydrofuran / 36 h / 60 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 4: |Michael Addition;

DOI:10.1016/j.ejmech.2012.07.021

Reference yield:

N,N-dimethylindoline-(2RS)-2-carboxamide (1400928-14-4) → C26H34N4O2 (1400928-22-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 36 h / 60 °C / Inert atmosphere

With triethylamine; In tetrahydrofuran; dichloromethane; 2: |Michael Addition;

DOI:10.1016/j.ejmech.2012.07.021

upstream raw materials:

1-t-butoxycarbonyl-2,3-dihydroindole-2-carboxylic acid

1-acryloyl-N,N-dimethylindoline-(2RS)-2-carboxamide

1-phenylethyl piperazine

N,N-dimethylindoline-(2RS)-2-carboxamide

Downstream raw materials:

N,N-dimethyl-1-{3-[4-(1-phenylethyl)piperazin-1-yl]propanoyl}indoline-(2RS)-2-carboxamide monocitrate

Refernces