((E)-3-Phenyl-allyloxy)-thioacetic acid S-[2-(2-iodo-phenyl)-ethyl] ester

Base Information

Chemical Name:((E)-3-Phenyl-allyloxy)-thioacetic acid S-[2-(2-iodo-phenyl)-ethyl] ester
CAS No.:177748-55-9
Molecular Formula:C₁₉H₁₉IO₂S
Molecular Weight:438.329
Hs Code.:

Synonyms:((E)-3-Phenyl-allyloxy)-thioacetic acid S-[2-(2-iodo-phenyl)-ethyl] ester

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Chemical Property of ((E)-3-Phenyl-allyloxy)-thioacetic acid S-[2-(2-iodo-phenyl)-ethyl] ester

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Technology Process of ((E)-3-Phenyl-allyloxy)-thioacetic acid S-[2-(2-iodo-phenyl)-ethyl] ester

There total 5 articles about ((E)-3-Phenyl-allyloxy)-thioacetic acid S-[2-(2-iodo-phenyl)-ethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 111009-36-0
(E)-3-phenylprop-2-enyloxyacetic acid

: 177748-62-8
2-(2-iodophenyl)-1-ethanethiol

: 177748-55-9
((E)-3-Phenyl-allyloxy)-thioacetic acid S-[2-(2-iodo-phenyl)-ethyl] ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; Ambient temperature;
DOI:10.1021/jo960115e

Reference yield:

: 26059-40-5
2-(2-iodophenyl)ethan-1-ol

: 177748-55-9
((E)-3-Phenyl-allyloxy)-thioacetic acid S-[2-(2-iodo-phenyl)-ethyl] ester

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / DEAD, PPh₃ / tetrahydrofuran / 20 h / Ambient temperature

2: 97 percent / DIBALH / diethyl ether; CH₂Cl₂ / 0.5 h / -78 - 0 °C

3: 94 percent / DMAP, DCC / CH₂Cl₂ / Ambient temperature

With dmap; diisobutylaluminium hydride; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo960115e

Reference yield:

: 1074-16-4
2-bromophenylethyl alcohol

: 177748-55-9
((E)-3-Phenyl-allyloxy)-thioacetic acid S-[2-(2-iodo-phenyl)-ethyl] ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / Et₃N / tetrahydrofuran / 2 h / Ambient temperature

2: 1.) BuLi, 2.) I₂ / 1.) THF, pentane, -78 deg C, 0.5 h, 2.) -> rt, 0.5 h

3: 78 percent / DEAD, PPh₃ / tetrahydrofuran / 20 h / Ambient temperature

4: 97 percent / DIBALH / diethyl ether; CH₂Cl₂ / 0.5 h / -78 - 0 °C

5: 94 percent / DMAP, DCC / CH₂Cl₂ / Ambient temperature

With dmap; n-butyllithium; iodine; diisobutylaluminium hydride; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo960115e