3-(1-Pyrrolidinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:3-(1-Pyrrolidinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
CAS No.:144243-26-5
Molecular Formula:C14H26 N2 O2
Molecular Weight:254.37
Hs Code.:
Mol file:144243-26-5.mol

Synonyms:1-Piperidinecarboxylicacid, 3-(1-pyrrolidinyl)-, 1,1-dimethylethyl ester, (?à)-

Suppliers and Price of 3-(1-Pyrrolidinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
3-(1-PYRROLIDINYL)-1-PIPERIDINECARBOXYLIC ACID-1,1-DIMETHYLETHYL ESTER 95.00%
5MG
$ 496.87

Total 3 raw suppliers

Chemical Property of 3-(1-Pyrrolidinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Chemical Property:

Boiling Point:333.0±35.0 °C(Predicted)
PKA:9.16±0.20(Predicted)
PSA：32.78000
Density:1.068±0.06 g/cm3(Predicted)
LogP:2.35750

Purity/Quality:

97% ^*data from raw suppliers

3-(1-PYRROLIDINYL)-1-PIPERIDINECARBOXYLIC ACID-1,1-DIMETHYLETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-(1-Pyrrolidinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

There total 8 articles about 3-(1-Pyrrolidinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 110-52-1
1,4-dibromo-butane

: 144243-24-3
tert‐butyl 3‐aminopiperidine‐1‐carboxylate

: 144243-26-5
1-(tert-butoxycarbonyl)-3-(1-pyrrolidinyl)piperidine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 55 ℃; for 72h;
DOI:10.1021/jm00101a011

Reference yield:

: 123-75-1
pyrrolidine

: 98977-36-7
3-oxo-piperidine-1-carboxylic acid tert-butyl ester

: 144243-26-5
1-(tert-butoxycarbonyl)-3-(1-pyrrolidinyl)piperidine

Guidance literature:: pyrrolidine; 3-oxo-piperidine-1-carboxylic acid tert-butyl ester; With acetic acid; In 1,2-dichloro-ethane; at 0 ℃; for 0.166667h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 0 - 20 ℃; for 16h;

Reference yield:

: 6859-99-0
3-hydroxypiperazine

: 144243-26-5
1-(tert-butoxycarbonyl)-3-(1-pyrrolidinyl)piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / aq. NaHCO₃ / 48 h / Ambient temperature

2: 96 percent / Et₃N / tetrahydrofuran / 1 h / Ambient temperature

3: 98 percent / NaN₃ / dimethylformamide / 48 h / 70 °C

4: 69 percent / H₂ / 10percent Pd/C / acetic acid; methanol / 24 h / 2585.7 Torr / Ambient temperature

5: 100 percent / K₂CO₃ / dimethylformamide / 72 h / 55 °C

With sodium azide; hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00101a011