(R)-2-benzyl-1-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine

Base Information

Chemical Name:(R)-2-benzyl-1-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine
CAS No.:1613165-15-3
Molecular Formula:C₂₀H₂₀N₂
Molecular Weight:288.392
Hs Code.:

Synonyms:(R)-2-benzyl-1-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-benzyl-1-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine

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Technology Process of (R)-2-benzyl-1-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine

There total 8 articles about (R)-2-benzyl-1-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1613164-95-6
2-benzyl-1-phenylpyrrolo[1,2-a]pyrazin-2-ium bromide

: 1613165-15-3
(R)-2-benzyl-1-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine

Guidance literature:: With bis(1,5-cyclooctadiene)diiridium(I) dichloride; (R_ax,S,S)-C₃-TunePhos; hydrogen; caesium carbonate; In tetrahydrofuran; at 20 ℃; for 24h; under 20686.5 Torr; Pressure; enantioselective reaction; Catalytic behavior; Autoclave;
DOI:10.1021/ol5013313

Reference yield:

: 98-80-6
phenylboronic acid

: 1613165-15-3
(R)-2-benzyl-1-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / benzene; ethanol; water / 80 °C / Inert atmosphere

2: acetone / 12 h / Reflux

3: hydrogen; bis(1,5-cyclooctadiene)diiridium(I) dichloride; (R_ax,S,S)-C₃-TunePhos; caesium carbonate / tetrahydrofuran / 24 h / 20 °C / 20686.5 Torr / Autoclave

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(1,5-cyclooctadiene)diiridium(I) dichloride; (R_ax,S,S)-C₃-TunePhos; hydrogen; sodium carbonate; caesium carbonate; In tetrahydrofuran; ethanol; water; acetone; benzene; 1: |Suzuki Coupling;
DOI:10.1021/ol5013313

Reference yield:

: 39573-69-8
1-Phenylpyrrolo<1,2-a>pyrazine

: 1613165-15-3
(R)-2-benzyl-1-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: acetone / 12 h / Reflux

2: hydrogen; bis(1,5-cyclooctadiene)diiridium(I) dichloride; (R_ax,S,S)-C₃-TunePhos; caesium carbonate / tetrahydrofuran / 24 h / 20 °C / 20686.5 Torr / Autoclave

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; (R_ax,S,S)-C₃-TunePhos; hydrogen; caesium carbonate; In tetrahydrofuran; acetone;
DOI:10.1021/ol5013313