1-[(2S,3S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-2-methyl-hexyloxymethyl]-4-methoxy-benzene

Base Information

Chemical Name:1-[(2S,3S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-2-methyl-hexyloxymethyl]-4-methoxy-benzene
CAS No.:157758-38-8
Molecular Formula:C₃₈H₅₈O₅Si₂
Molecular Weight:651.047
Hs Code.:

Synonyms:1-[(2S,3S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-2-methyl-hexyloxymethyl]-4-methoxy-benzene

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Chemical Property of 1-[(2S,3S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-2-methyl-hexyloxymethyl]-4-methoxy-benzene

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Technology Process of 1-[(2S,3S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-2-methyl-hexyloxymethyl]-4-methoxy-benzene

There total 6 articles about 1-[(2S,3S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-2-methyl-hexyloxymethyl]-4-methoxy-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: (2S,3S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-2-methyl-hexan-1-ol

: 157758-38-8
1-[(2S,3S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-2-methyl-hexyloxymethyl]-4-methoxy-benzene

Guidance literature:: With camphor-10-sulfonic acid; In dichloromethane; at 25 ℃; for 14h;
DOI:10.1039/c39940001147

Reference yield:

: 124655-05-6
(S)-methyl 4-(tert-butyldiphenylsilyloxy)-3-hydroxybutanoate

: 157758-38-8
1-[(2S,3S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-2-methyl-hexyloxymethyl]-4-methoxy-benzene

Guidance literature:: Multi-step reaction with 6 steps

1: 86 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 25 °C

2: 96 percent / DIBAL, MeOH / CH₂Cl₂ / 0.5 h / -78 °C

3: 1.) t-BuOK, n-BuLi, 2.) (+)-β-methoxydiisopinocamphenylborane, BF3*OEt2, 3.) aq. H2O2, NaOH

4: 91 percent / NaH / tetrahydrofuran / 14 h / 0 °C

5: 1.) O₃, 2.) NaBH₄ / 1.) CH₂Cl₂, MeOH, -78 deg C, 2.) CH₂Cl₂, MeOH, -78 deg C

6: 83 percent / camphorosulfonic acid / CH₂Cl₂ / 14 h / 25 °C

With 2,6-dimethylpyridine; methanol; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; potassium tert-butylate; dihydrogen peroxide; sodium hydride; diisobutylaluminium hydride; ozone; (+)-B-methoxydiisocamphenylborane; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c39940001147

Reference yield:

: 157758-37-7
(3S,4S,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxy)-3-methyl-hept-1-en-4-ol

: 157758-38-8
1-[(2S,3S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-2-methyl-hexyloxymethyl]-4-methoxy-benzene

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / NaH / tetrahydrofuran / 14 h / 0 °C

2: 1.) O₃, 2.) NaBH₄ / 1.) CH₂Cl₂, MeOH, -78 deg C, 2.) CH₂Cl₂, MeOH, -78 deg C

3: 83 percent / camphorosulfonic acid / CH₂Cl₂ / 14 h / 25 °C

With sodium tetrahydroborate; camphor-10-sulfonic acid; sodium hydride; ozone; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c39940001147