(S)-methyl 3-(tert-butyldimethylsilyloxy)-4-(tert-butyldiphenylsilyloxy)butanoate

Base Information

Chemical Name:(S)-methyl 3-(tert-butyldimethylsilyloxy)-4-(tert-butyldiphenylsilyloxy)butanoate
CAS No.:157758-36-6
Molecular Formula:C₂₇H₄₂O₄Si₂
Molecular Weight:486.799
Hs Code.:

Synonyms:(S)-methyl 3-(tert-butyldimethylsilyloxy)-4-(tert-butyldiphenylsilyloxy)butanoate

Suppliers and Price of (S)-methyl 3-(tert-butyldimethylsilyloxy)-4-(tert-butyldiphenylsilyloxy)butanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (S)-methyl 3-(tert-butyldimethylsilyloxy)-4-(tert-butyldiphenylsilyloxy)butanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-methyl 3-(tert-butyldimethylsilyloxy)-4-(tert-butyldiphenylsilyloxy)butanoate

There total 3 articles about (S)-methyl 3-(tert-butyldimethylsilyloxy)-4-(tert-butyldiphenylsilyloxy)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 124655-05-6
(S)-methyl 4-(tert-butyldiphenylsilyloxy)-3-hydroxybutanoate

: 157758-36-6
(S)-methyl 3-(tert-butyldimethylsilyloxy)-4-(tert-butyldiphenylsilyloxy)butanoate

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 25 ℃; for 2h;
DOI:10.1039/c39940001147

Reference yield:

: 617-55-0
dimethyl (S)-malate

: 157758-36-6
(S)-methyl 3-(tert-butyldimethylsilyloxy)-4-(tert-butyldiphenylsilyloxy)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) BH₃*SMe₂, 2.) NaBH₄ / 1.) -78 deg C, 30 min, 2.) THF, 0 deg C, 4 h

2: 91 percent / Et₃N, DMAP / CH₂Cl₂ / 14 h / 25 °C

3: 86 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 25 °C

With 2,6-dimethylpyridine; dmap; sodium tetrahydroborate; dimethylsulfide borane complex; triethylamine; In dichloromethane;
DOI:10.1039/c39940001147

Reference yield:

: 90414-36-1
methyl (3S)-3,4-dihydroxybutyrate

: 157758-36-6
(S)-methyl 3-(tert-butyldimethylsilyloxy)-4-(tert-butyldiphenylsilyloxy)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / Et₃N, DMAP / CH₂Cl₂ / 14 h / 25 °C

2: 86 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 25 °C

With 2,6-dimethylpyridine; dmap; triethylamine; In dichloromethane;
DOI:10.1039/c39940001147