4-(5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine

Base Information

Chemical Name:4-(5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine
CAS No.:1287783-15-6
Molecular Formula:C₂₁H₂₄FNO₄
Molecular Weight:373.424
Hs Code.:

Synonyms:4-(5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine

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Chemical Property of 4-(5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine

Chemical Property:

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Technology Process of 4-(5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine

There total 12 articles about 4-(5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.4%

: 1287783-14-5
tert-butyl 4-(5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)phenyl-N-methylcarbamate

: 1287783-15-6
4-(5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm200057u

Reference yield:

: 888703-98-8
2-(4'-aminophenyl)-5-methoxybenzo[b]furan

: 1287783-15-6
4-(5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium methylate / methanol / 1 h / Reflux

1.2: 2 h / Reflux

2.1: boron tribromide / dichloromethane / 1 h / 20 °C / Cooling with ice

2.2: Cooling with ice

3.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

4.1: 1H-imidazole / dichloromethane / 4 h / 20 °C

5.1: tetrahydrofuran / Reflux

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

7.1: triethylamine / dichloromethane / 2 h / 20 °C

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / Reflux

9.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; sodium methylate; boron tribromide; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm200057u

Reference yield:

: 888703-97-7
2-(4'-nitrophenyl)-5-methoxybenzo[b]furan

: 1287783-15-6
4-(5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine

Guidance literature:: Multi-step reaction with 10 steps

1.1: tin(ll) chloride / ethanol / 2 h / Reflux

2.1: sodium methylate / methanol / 1 h / Reflux

2.2: 2 h / Reflux

3.1: boron tribromide / dichloromethane / 1 h / 20 °C / Cooling with ice

3.2: Cooling with ice

4.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

5.1: 1H-imidazole / dichloromethane / 4 h / 20 °C

6.1: tetrahydrofuran / Reflux

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

8.1: triethylamine / dichloromethane / 2 h / 20 °C

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / Reflux

10.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; sodium methylate; boron tribromide; potassium carbonate; triethylamine; trifluoroacetic acid; tin(ll) chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm200057u