4-(tert-Butyl-dimethyl-silanyloxy)-4-(2-iodo-phenyl)-butan-1-ol

Base Information

• Chemical Name: 4-(tert-Butyl-dimethyl-silanyloxy)-4-(2-iodo-phenyl)-butan-1-ol
• CAS No.: 146563-22-6
• Molecular Formula: C₁₆H₂₇IO₂Si
• Molecular Weight: 406.379
• Mol file: 146563-22-6.mol

Synonyms:4-(tert-Butyl-dimethyl-silanyloxy)-4-(2-iodo-phenyl)-butan-1-ol

Chemical Property of 4-(tert-Butyl-dimethyl-silanyloxy)-4-(2-iodo-phenyl)-butan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4-(tert-Butyl-dimethyl-silanyloxy)-4-(2-iodo-phenyl)-butan-1-ol

There total 3 articles about 4-(tert-Butyl-dimethyl-silanyloxy)-4-(2-iodo-phenyl)-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-iodobenzaldehyde (26260-02-6) → 4-(tert-Butyl-dimethyl-silanyloxy)-4-(2-iodo-phenyl)-butan-1-ol (146563-22-6)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran; diethyl ether / 96 h

2: 86 percent / imidazole / dimethylformamide

3: 1.) BH₃, SMe₂, 2.) H₂O₂, NaOH / 1,) hexane, rt, overnoght, 2.) EtOH, hexane, H₂O, reflux, 5 h

With 1H-imidazole; sodium hydroxide; dimethylsulfide; borane; dihydrogen peroxide; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1021/ja972427k

Reference yield:

1-(2-iodophenyl)-1-hydroxy-3-butene (148761-94-8) → 4-(tert-Butyl-dimethyl-silanyloxy)-4-(2-iodo-phenyl)-butan-1-ol (146563-22-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / imidazole / dimethylformamide

2: 1.) BH₃, SMe₂, 2.) H₂O₂, NaOH / 1,) hexane, rt, overnoght, 2.) EtOH, hexane, H₂O, reflux, 5 h

With 1H-imidazole; sodium hydroxide; dimethylsulfide; borane; dihydrogen peroxide; In N,N-dimethyl-formamide;

DOI:10.1021/ja972427k

Reference yield:

tert-butyl ((1-(2-iodophenyl)but-3-en-1-yl)oxy)dimethylsilane (148762-10-1) → 4-(tert-Butyl-dimethyl-silanyloxy)-4-(2-iodo-phenyl)-butan-1-ol (146563-22-6)

Guidance literature:

With sodium hydroxide; dimethylsulfide borane complex; dihydrogen peroxide; Yield given. Multistep reaction; 1.) hexane, 23 deg C;

DOI:10.1021/ja00058a064

upstream raw materials:

tert-butyl ((1-(2-iodophenyl)but-3-en-1-yl)oxy)dimethylsilane

2-iodobenzaldehyde

1-(2-iodophenyl)-1-hydroxy-3-butene

Downstream raw materials:

4-(tert-Butyl-dimethyl-silanyloxy)-4-(2-iodo-phenyl)-butyraldehyde

2-[2-(2-iodophenyl)2-oxoethyl]-5-methyl-1-methylenecyclohept-4-ene

2-[2-hydroxy-2-(2-iodophenyl)ethyl]-5-methyl-1-methylenecyclohept-4-ene

tert-Butyl-[1-(2-iodo-phenyl)-2-(4-methyl-7-methylene-cyclohept-3-enyl)-ethoxy]-dimethyl-silane