diethyl (2S)-2-{[(2S)-2-({[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]methyl}amino)-3-phenylpropanoyl]amino}pentanedioate

Base Information

Chemical Name:diethyl (2S)-2-{[(2S)-2-({[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]methyl}amino)-3-phenylpropanoyl]amino}pentanedioate
CAS No.:853657-91-7
Molecular Formula:C₃₅H₃₈N₄O₇
Molecular Weight:626.709
Hs Code.:

Synonyms:diethyl (2S)-2-{[(2S)-2-({[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]methyl}amino)-3-phenylpropanoyl]amino}pentanedioate

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Chemical Property of diethyl (2S)-2-{[(2S)-2-({[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]methyl}amino)-3-phenylpropanoyl]amino}pentanedioate

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Technology Process of diethyl (2S)-2-{[(2S)-2-({[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]methyl}amino)-3-phenylpropanoyl]amino}pentanedioate

There total 7 articles about diethyl (2S)-2-{[(2S)-2-({[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]methyl}amino)-3-phenylpropanoyl]amino}pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 853657-90-6
(2S)-2-({[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]methyl}amino)-3-phenyl-propanoic acid

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 853657-91-7
diethyl (2S)-2-{[(2S)-2-({[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]methyl}amino)-3-phenylpropanoyl]amino}pentanedioate

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); for 4h; pH=7;

Reference yield:

: 852233-77-3
ethyl 2-(5-formyl-2-nitrophenoxy)acetate

: 853657-91-7
diethyl (2S)-2-{[(2S)-2-({[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]methyl}amino)-3-phenylpropanoyl]amino}pentanedioate

Guidance literature:: Multi-step reaction with 5 steps

1: 64 percent / SnCl₂*2H₂O / ethanol / 0.5 h / 70 °C

2: 84 percent / benzyltriethylammonium chloride; potassium carbonate / acetonitrile / 60 °C

3: 82 percent / sodium triacetoxyborohydride; triethylamine / 1,2-dichloro-ethane / 24 h / 20 °C

4: aq. NaOH / ethanol / 20 °C

5: 1-hydroxybanzotriazole; N-methylmorpholine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / pH 7

With 4-methyl-morpholine; sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; sodium tris(acetoxy)borohydride; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; tin(ll) chloride; In ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm048984g

Reference yield:

: 852233-78-4
4-[(7-formyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)methyl]-benzonitrile

: 853657-91-7
diethyl (2S)-2-{[(2S)-2-({[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]methyl}amino)-3-phenylpropanoyl]amino}pentanedioate

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / sodium triacetoxyborohydride; triethylamine / 1,2-dichloro-ethane / 24 h / 20 °C

2: aq. NaOH / ethanol / 20 °C

3: 1-hydroxybanzotriazole; N-methylmorpholine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / pH 7

With 4-methyl-morpholine; sodium hydroxide; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm048984g