ethyl (2S)-2-({[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]methyl}-amino)-3-phenylpropanoate

Base Information

Chemical Name:ethyl (2S)-2-({[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]methyl}-amino)-3-phenylpropanoate
CAS No.:852233-71-7
Molecular Formula:C₂₈H₂₇N₃O₄
Molecular Weight:469.54
Hs Code.:

Synonyms:ethyl (2S)-2-({[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]methyl}-amino)-3-phenylpropanoate

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Chemical Property of ethyl (2S)-2-({[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]methyl}-amino)-3-phenylpropanoate

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Technology Process of ethyl (2S)-2-({[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]methyl}-amino)-3-phenylpropanoate

There total 5 articles about ethyl (2S)-2-({[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]methyl}-amino)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 852233-78-4
4-[(7-formyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)methyl]-benzonitrile

: 3182-93-2
(L)-phenylalanine ethyl ester hydrochloride

: 852233-71-7
ethyl (2S)-2-({[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]methyl}-amino)-3-phenylpropanoate

Guidance literature:: With sodium tris(acetoxy)borohydride; triethylamine; In 1,2-dichloro-ethane; at 20 ℃; for 24h;

Reference yield: 82.0%

: 852233-78-4
4-[(7-formyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)methyl]-benzonitrile

: 63060-94-6
D-phenylalanine ethyl ester hydrochloride

: 852233-71-7
ethyl (2S)-2-({[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]methyl}-amino)-3-phenylpropanoate

Guidance literature:: With sodium tris(acetoxy)borohydride; triethylamine; In 1,2-dichloro-ethane; at 20 ℃; for 24h;
DOI:10.1021/jm048984g

Reference yield:

: 852233-77-3
ethyl 2-(5-formyl-2-nitrophenoxy)acetate

: 852233-71-7
ethyl (2S)-2-({[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]methyl}-amino)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / SnCl₂*2H₂O / ethanol / 0.5 h / 70 °C

2: 84 percent / benzyltriethylammonium chloride; potassium carbonate / acetonitrile / 60 °C

3: 82 percent / sodium triacetoxyborohydride; triethylamine / 1,2-dichloro-ethane / 24 h / 20 °C

With N-benzyl-N,N,N-triethylammonium chloride; sodium tris(acetoxy)borohydride; potassium carbonate; triethylamine; tin(ll) chloride; In ethanol; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/jm048984g