(2R,4E,7R)-2-(tert-butyloxycarbonylamino)-7-(benzyloxycarbonylamino)-1-(3-indolyl)-8-phenyloct-4-en-3-one

Base Information

Chemical Name:(2R,4E,7R)-2-(tert-butyloxycarbonylamino)-7-(benzyloxycarbonylamino)-1-(3-indolyl)-8-phenyloct-4-en-3-one
CAS No.:610772-74-2
Molecular Formula:C₃₅H₃₉N₃O₅
Molecular Weight:581.712
Hs Code.:

Synonyms:(2R,4E,7R)-2-(tert-butyloxycarbonylamino)-7-(benzyloxycarbonylamino)-1-(3-indolyl)-8-phenyloct-4-en-3-one

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Chemical Property of (2R,4E,7R)-2-(tert-butyloxycarbonylamino)-7-(benzyloxycarbonylamino)-1-(3-indolyl)-8-phenyloct-4-en-3-one

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Technology Process of (2R,4E,7R)-2-(tert-butyloxycarbonylamino)-7-(benzyloxycarbonylamino)-1-(3-indolyl)-8-phenyloct-4-en-3-one

There total 3 articles about (2R,4E,7R)-2-(tert-butyloxycarbonylamino)-7-(benzyloxycarbonylamino)-1-(3-indolyl)-8-phenyloct-4-en-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 868670-42-2
((S)-1-Benzyl-3-oxo-propyl)-carbamic acid benzyl ester

: 610772-63-9
(3R)-3-(tert-butyloxycarbonylamino)-1-(dimethoxyphosphoryl)-4-(3-indolyl)butan-2-one

: 610772-74-2
(2R,4E,7R)-2-(tert-butyloxycarbonylamino)-7-(benzyloxycarbonylamino)-1-(3-indolyl)-8-phenyloct-4-en-3-one

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; for 16h;
DOI:10.1002/ejoc.200300148

Reference yield:

: {(S)-1-[(Methoxy-methyl-carbamoyl)-methyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

: 610772-74-2
(2R,4E,7R)-2-(tert-butyloxycarbonylamino)-7-(benzyloxycarbonylamino)-1-(3-indolyl)-8-phenyloct-4-en-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran / 0.17 h / 0 °C

2: K₂CO₃ / acetonitrile / 16 h / 20 °C

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; acetonitrile; 2: Horner-Wadsworth-Emmons condensation;
DOI:10.1002/ejoc.200300148

Reference yield:

: (R)-tert-butyl (3-(1H-indol-3-yl)-1-(methoxy(methyl)amino)-1-oxopropan-2-yl)carbamate

: 610772-74-2
(2R,4E,7R)-2-(tert-butyloxycarbonylamino)-7-(benzyloxycarbonylamino)-1-(3-indolyl)-8-phenyloct-4-en-3-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: BuLi / tetrahydrofuran; hexane / 0.17 h / -78 - -70 °C

1.2: 75 percent / tetrahydrofuran; hexane / 0.5 h / -70 °C

2.1: K₂CO₃ / acetonitrile / 16 h / 20 °C

With n-butyllithium; potassium carbonate; In tetrahydrofuran; hexane; acetonitrile; 2.1: Horner-Wadsworth-Emmons condensation;
DOI:10.1002/ejoc.200300148