4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-3-fluorophenylsulfamate

Base Information

Chemical Name:4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-3-fluorophenylsulfamate
CAS No.:1472067-88-1
Molecular Formula:C₁₆H₁₃FN₆O₃S
Molecular Weight:388.382
Hs Code.:

Synonyms:4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-3-fluorophenylsulfamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-3-fluorophenylsulfamate

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Technology Process of 4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-3-fluorophenylsulfamate

There total 5 articles about 4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-3-fluorophenylsulfamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1472068-01-1
4-[(2-fluoro-4-hydroxybenzyl)(4H-1,2,4-triazol-4-yl)amino]benzonitrile

: 1472067-88-1
4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-3-fluorophenylsulfamate

Guidance literature:: With sulphamoyl chloride; In N,N-dimethyl acetamide; at 0 - 20 ℃;
DOI:10.1002/cmdc.201300015

Reference yield:

: 96740-92-0
3-fluoro-4-(hydroxymethyl)phenol

: 1472067-88-1
4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-3-fluorophenylsulfamate

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 2 h

2: potassium carbonate / N,N-dimethyl-formamide / 48 h

3: sulphamoyl chloride / N,N-dimethyl acetamide / 0 - 20 °C

With thionyl chloride; sulphamoyl chloride; potassium carbonate; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201300015

Reference yield:

: 197507-22-5
methyl 2-fluoro-4-hydroxybenzoate

: 1472067-88-1
4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-3-fluorophenylsulfamate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0.75 h / 20 °C

2: thionyl chloride / 2 h

3: potassium carbonate / N,N-dimethyl-formamide / 48 h

4: sulphamoyl chloride / N,N-dimethyl acetamide / 0 - 20 °C

With lithium aluminium tetrahydride; thionyl chloride; sulphamoyl chloride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201300015