4-Acetyl-7-(2-methoxy-phenoxy)-3a,4,5,6,9,10-hexahydro-3H-furo[3,4-j]isoquinoline-1,8-dione

Base Information

Chemical Name:4-Acetyl-7-(2-methoxy-phenoxy)-3a,4,5,6,9,10-hexahydro-3H-furo[3,4-j]isoquinoline-1,8-dione
CAS No.:98689-13-5
Molecular Formula:C₂₀H₂₁NO₆
Molecular Weight:371.39
Hs Code.:

Synonyms:4-Acetyl-7-(2-methoxy-phenoxy)-3a,4,5,6,9,10-hexahydro-3H-furo[3,4-j]isoquinoline-1,8-dione

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Chemical Property of 4-Acetyl-7-(2-methoxy-phenoxy)-3a,4,5,6,9,10-hexahydro-3H-furo[3,4-j]isoquinoline-1,8-dione

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Technology Process of 4-Acetyl-7-(2-methoxy-phenoxy)-3a,4,5,6,9,10-hexahydro-3H-furo[3,4-j]isoquinoline-1,8-dione

There total 1 articles about 4-Acetyl-7-(2-methoxy-phenoxy)-3a,4,5,6,9,10-hexahydro-3H-furo[3,4-j]isoquinoline-1,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 75-36-5
acetyl chloride

: 98689-11-3
7-(2-Methoxy-phenoxy)-3a,4,5,6,9,10-hexahydro-3H-furo[3,4-j]isoquinoline-1,8-dione

: 98689-13-5
4-Acetyl-7-(2-methoxy-phenoxy)-3a,4,5,6,9,10-hexahydro-3H-furo[3,4-j]isoquinoline-1,8-dione

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; 1.) 0 deg C, 15 min, 2.) RT, 0.5 h;
DOI:10.1021/jo00223a001

Reference yield:

: 98689-13-5
4-Acetyl-7-(2-methoxy-phenoxy)-3a,4,5,6,9,10-hexahydro-3H-furo[3,4-j]isoquinoline-1,8-dione

: 98689-15-7
4-Acetyl-7-(2-hydroxy-phenoxy)-3a,4,5,6,9,10-hexahydro-3H-furo[3,4-j]isoquinoline-1,8-dione

Guidance literature:: With boron tribromide; In dichloromethane; at -78 ℃; for 0.0833333h;
DOI:10.1021/jo00223a001

Reference yield:

: 98689-13-5
4-Acetyl-7-(2-methoxy-phenoxy)-3a,4,5,6,9,10-hexahydro-3H-furo[3,4-j]isoquinoline-1,8-dione

: 98689-14-6
Acetic acid 2-(4-acetyl-1,8-dioxo-3,3a,4,5,6,8,9,10-octahydro-furo[3,4-j]isoquinolin-7-yloxy)-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: boron tribromide / CH₂Cl₂ / 0.08 h / -78 °C

2: pyridine / 4.5 h / Ambient temperature

With pyridine; boron tribromide; In dichloromethane;
DOI:10.1021/jo00223a001