1-cyclopropyl-3-(4-(2-(5-((2,5-dioxopyrrolidin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)urea

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Chemical Name:1-cyclopropyl-3-(4-(2-(5-((2,5-dioxopyrrolidin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)urea
CAS No.:1342827-16-0
Molecular Formula:C₂₇H₂₂FN₅O₄S
Molecular Weight:531.567
Hs Code.:

Synonyms:1-cyclopropyl-3-(4-(2-(5-((2,5-dioxopyrrolidin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)urea

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Chemical Property of 1-cyclopropyl-3-(4-(2-(5-((2,5-dioxopyrrolidin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)urea

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Technology Process of 1-cyclopropyl-3-(4-(2-(5-((2,5-dioxopyrrolidin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)urea

There total 4 articles about 1-cyclopropyl-3-(4-(2-(5-((2,5-dioxopyrrolidin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 1342834-64-3
1-((6-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)pyrrolidine-2,5-dione

: 765-30-0
Cyclopropylamine

: 1342827-16-0
1-cyclopropyl-3-(4-(2-(5-((2,5-dioxopyrrolidin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)urea

Guidance literature:: With triethanolamine; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 1342834-30-3
(6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methanol

: 1342827-16-0
1-cyclopropyl-3-(4-(2-(5-((2,5-dioxopyrrolidin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride

2: caesium carbonate / N,N-dimethyl-formamide

3: ammonium chloride; zinc / water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

4: triethanolamine / ethyl acetate; tetrahydrofuran

With triethanolamine; ammonium chloride; caesium carbonate; zinc; In tetrahydrofuran; thionyl chloride; water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1342834-32-5
2-(5-(chloromethyl)pyridin-2-yl)-7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]-pyridine

: 1342827-16-0
1-cyclopropyl-3-(4-(2-(5-((2,5-dioxopyrrolidin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide

2: ammonium chloride; zinc / water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

3: triethanolamine / ethyl acetate; tetrahydrofuran

With triethanolamine; ammonium chloride; caesium carbonate; zinc; In tetrahydrofuran; water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; ethyl acetate; N,N-dimethyl-formamide;