N-(5-tert-butyldimethylsilyloxy-2-iodobenzyl)-N-methyl-α-phenylphenacylamine

Base Information

Chemical Name:N-(5-tert-butyldimethylsilyloxy-2-iodobenzyl)-N-methyl-α-phenylphenacylamine
CAS No.:191536-03-5
Molecular Formula:C₂₈H₃₄INO₂Si
Molecular Weight:571.573
Hs Code.:

Synonyms:N-(5-tert-butyldimethylsilyloxy-2-iodobenzyl)-N-methyl-α-phenylphenacylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(5-tert-butyldimethylsilyloxy-2-iodobenzyl)-N-methyl-α-phenylphenacylamine

Chemical Property:

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Technology Process of N-(5-tert-butyldimethylsilyloxy-2-iodobenzyl)-N-methyl-α-phenylphenacylamine

There total 6 articles about N-(5-tert-butyldimethylsilyloxy-2-iodobenzyl)-N-methyl-α-phenylphenacylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 191536-00-2
5-tert-butyldimethylsilyloxy-2-iodo-N-methylbenzylamine

: 1484-50-0
desyl bromide

: 191536-03-5
N-(5-tert-butyldimethylsilyloxy-2-iodobenzyl)-N-methyl-α-phenylphenacylamine

Guidance literature:: With methyloxirane; In 1,4-dioxane; for 2h; Heating;
DOI:10.1248/cpb.45.939

Reference yield:

: 96013-95-5
3-(tert-butyl-dimethyl-sylanyloxy)benzaldehyde

: 191536-03-5
N-(5-tert-butyldimethylsilyloxy-2-iodobenzyl)-N-methyl-α-phenylphenacylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / NaBH₄ / methanol / 0.17 h / 0 °C

2: 78 percent / I₂, CF₃COOAg / CH₂Cl₂ / 0.08 h / Ambient temperature

3: 96 percent / pyridinium chlorochromate / CH₂Cl₂ / 2.5 h / Ambient temperature

4: 2.) NaBH₄, 2 N HCl / 1.) MeOH, reflux, 1 h, 2.) MeOH, RT, 2 h

5: 85 percent / propylene oxide / dioxane / 2 h / Heating

With hydrogenchloride; sodium tetrahydroborate; iodine; silver trifluoroacetate; pyridinium chlorochromate; methyloxirane; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1248/cpb.45.939

Reference yield:

: 96013-77-3
3-(tert-butyldimethylsilyloxy)benzyl alcohol

: 191536-03-5
N-(5-tert-butyldimethylsilyloxy-2-iodobenzyl)-N-methyl-α-phenylphenacylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / I₂, CF₃COOAg / CH₂Cl₂ / 0.08 h / Ambient temperature

2: 96 percent / pyridinium chlorochromate / CH₂Cl₂ / 2.5 h / Ambient temperature

3: 2.) NaBH₄, 2 N HCl / 1.) MeOH, reflux, 1 h, 2.) MeOH, RT, 2 h

4: 85 percent / propylene oxide / dioxane / 2 h / Heating

With hydrogenchloride; sodium tetrahydroborate; iodine; silver trifluoroacetate; pyridinium chlorochromate; methyloxirane; In 1,4-dioxane; dichloromethane;
DOI:10.1248/cpb.45.939