tert-butyldimethylsilyl 3-((αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-(tert-butyldimethylsilyloxy)benzyl)benzoate

Base Information

Chemical Name:tert-butyldimethylsilyl 3-((αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-(tert-butyldimethylsilyloxy)benzyl)benzoate
CAS No.:168155-49-5
Molecular Formula:C₃₅H₅₆N₂O₃Si₂
Molecular Weight:609.012
Hs Code.:

Synonyms:tert-butyldimethylsilyl 3-((αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-(tert-butyldimethylsilyloxy)benzyl)benzoate

Suppliers and Price of tert-butyldimethylsilyl 3-((αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-(tert-butyldimethylsilyloxy)benzyl)benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyldimethylsilyl 3-((αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-(tert-butyldimethylsilyloxy)benzyl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyldimethylsilyl 3-((αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-(tert-butyldimethylsilyloxy)benzyl)benzoate

There total 9 articles about tert-butyldimethylsilyl 3-((αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-(tert-butyldimethylsilyloxy)benzyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 168749-06-2
(+)-3-((αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)benzoic acid

: 168155-49-5
tert-butyldimethylsilyl 3-((αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-(tert-butyldimethylsilyloxy)benzyl)benzoate

Guidance literature:: With 1H-imidazole; sodium chloride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm020395s

Reference yield:

: 288-32-4
1H-imidazole

: 18162-48-6
tert-butyldimethylsilyl chloride

: 168749-06-2
(+)-3-((αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)benzoic acid

: 168155-49-5
tert-butyldimethylsilyl 3-((αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-(tert-butyldimethylsilyloxy)benzyl)benzoate

Guidance literature:: In N-methyl-acetamide; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; water;

Reference yield:

: 591-20-8
3-Bromophenol

: 168155-49-5
tert-butyldimethylsilyl 3-((αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-(tert-butyldimethylsilyloxy)benzyl)benzoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: imidazole / dimethylformamide / 18 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C

2.2: tetrahydrofuran; hexane / 2 h / -78 °C

3.1: thionyl chloride / CH₂Cl₂ / 20 °C

4.1: acetonitrile / 48 h / Heating

5.1: tetraethylammonium fluoride dihydrate / acetonitrile / 1 h / 20 °C

6.1: 58 percent / 1-methyl-pyrrolidin-2-one / 30 h / 170 °C

7.1: NaOH / aq. ethanol / 72 h / Heating

8.1: imidazole; NaCl / dimethylformamide / 20 °C

With 1H-imidazole; sodium hydroxide; n-butyllithium; thionyl chloride; tetraethylammonium fluoride; sodium chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm020395s