2-hydroxy-5-methyl-3-[3-(2,3,6-trichlorophenyl)-acryloyl]-benzoic acid

Base Information

Chemical Name:2-hydroxy-5-methyl-3-[3-(2,3,6-trichlorophenyl)-acryloyl]-benzoic acid
CAS No.:1289080-29-0
Molecular Formula:C₁₇H₁₁Cl₃O₄
Molecular Weight:385.631
Hs Code.:

Synonyms:2-hydroxy-5-methyl-3-[3-(2,3,6-trichlorophenyl)-acryloyl]-benzoic acid

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Chemical Property of 2-hydroxy-5-methyl-3-[3-(2,3,6-trichlorophenyl)-acryloyl]-benzoic acid

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Technology Process of 2-hydroxy-5-methyl-3-[3-(2,3,6-trichlorophenyl)-acryloyl]-benzoic acid

There total 3 articles about 2-hydroxy-5-methyl-3-[3-(2,3,6-trichlorophenyl)-acryloyl]-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.5%

: 4659-47-6
2,3,6-trichlorobenzaldehyde

: 1760-83-4
3-carboxy-2-hydroxy-5-methylacetophenone

: 1289080-29-0
2-hydroxy-5-methyl-3-[3-(2,3,6-trichlorophenyl)-acryloyl]-benzoic acid

Guidance literature:: 2,3,6-trichlorobenzaldehyde; 3-carboxy-2-hydroxy-5-methylacetophenone; With sodium hydroxide; In ethanol; water; at 20 ℃;

With hydrogenchloride; In ethanol; water; pH=4;
DOI:10.1016/j.bmc.2011.01.047

Reference yield:

: 89-56-5
5-Methylsalicylic acid

: 1289080-29-0
2-hydroxy-5-methyl-3-[3-(2,3,6-trichlorophenyl)-acryloyl]-benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / 0.33 h

2.1: aluminum (III) chloride / 3 h / 160 °C / Neat (no solvent)

3.1: sodium hydroxide / ethanol; water / 20 °C

3.2: pH 4

With aluminum (III) chloride; sulfuric acid; sodium hydroxide; In ethanol; water; 2.1: Fries rearrangement / 3.1: Claisen Schmidt condensation;
DOI:10.1016/j.bmc.2011.01.047

Reference yield:

: 14504-08-6
2-acetoxy-5-methylbenzoic acid

: 1289080-29-0
2-hydroxy-5-methyl-3-[3-(2,3,6-trichlorophenyl)-acryloyl]-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / 3 h / 160 °C / Neat (no solvent)

2.1: sodium hydroxide / ethanol; water / 20 °C

2.2: pH 4

With aluminum (III) chloride; sodium hydroxide; In ethanol; water; 1.1: Fries rearrangement / 2.1: Claisen Schmidt condensation;
DOI:10.1016/j.bmc.2011.01.047