2-Pyrrolidinecarboxaldehyde,1-(1-butenyl)-5-oxo-,(S)-(9CI)

Base Information

• Chemical Name: 2-Pyrrolidinecarboxaldehyde,1-(1-butenyl)-5-oxo-,(S)-(9CI)
• CAS No.: 144085-12-1
• Molecular Formula: C₉H₁₃NO₂
• Molecular Weight: 167.208
• Hs Code.: 2933790090
• Mol file: 144085-12-1.mol

Synonyms:2-Pyrrolidinecarboxaldehyde,1-(1-butenyl)-5-oxo-,(S)-(9CI)

Chemical Property of 2-Pyrrolidinecarboxaldehyde,1-(1-butenyl)-5-oxo-,(S)-(9CI)

Chemical Property:

• Boiling Point: 312.8±31.0 °C(Predicted)
• PKA: -2.08±0.40(Predicted)
• PSA: 37.38000
• Density: 1.236±0.06 g/cm3(Predicted)
• LogP: 1.03790
• Storage Temp.: 2-8°C

Purity/Quality:

99%+ ^*data from raw suppliers

(S,E)-1-(But-1-en-1-yl)-5-oxopyrrolidine-2-carbaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyrrolidinecarboxaldehyde,1-(1-butenyl)-5-oxo-,(S)-(9CI)

There total 6 articles about 2-Pyrrolidinecarboxaldehyde,1-(1-butenyl)-5-oxo-,(S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(S)-(+)-5-(hydroxymethyl)-N-(1-butenyl)-2-pyrrolidinone (139694-77-2) → (S)-(+)-N-(1-butenyl)-2-pyrrolidinone-5-carboxaldehyde (144085-12-1)

Guidance literature:

With dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In benzene; for 14h;

Reference yield: 77.0%

(S)-(+)-5-(hydroxymethyl)-(1-butenyl)-2-pyrrolidinone (139694-77-2) → (S)-(+)-N-(1-butenyl)-2-oxopyrrolidine-5-carboxaldehyde (144085-12-1)

Guidance literature:

With pyridine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dimethyl sulfoxide; benzene; for 18h; Ambient temperature;

DOI:10.1021/jo00049a023

Reference yield: 19.0%

(S)-(+)-5-carboethoxy-N-(1-butenyl)-2-pyrrolidinone (139694-76-1) → (S)-(+)-N-(1-butenyl)-2-pyrrolidinone-5-carboxaldehyde (144085-12-1)

Guidance literature:

With lithium-tris(diethylamino)hydridoaluminate; In tetrahydrofuran; for 24h; Ambient temperature;

DOI:10.1080/00397919608004620

upstream raw materials:

(S)-(+)-5-(hydroxymethyl)-N-(1-butenyl)-2-pyrrolidinone

(S)-(+)-5-carboethoxy-N-(1-butenyl)-2-pyrrolidinone

(S)-(+)-5-(hydroxymethyl)-(1-butenyl)-2-pyrrolidinone

L-glutamic acid

Downstream raw materials:

(+)-Vigabatrin

(-)-isoretronecanol