(3R)-1-azabicyclo[2.2.2]oct-3-yl (5-phenyl-1,3-oxazol-4-yl)carbamate hydrochloride

Base Information

Chemical Name:(3R)-1-azabicyclo[2.2.2]oct-3-yl (5-phenyl-1,3-oxazol-4-yl)carbamate hydrochloride
CAS No.:1047672-15-0
Molecular Formula:C₁₇H₁₉N₃O₃*ClH
Molecular Weight:349.817
Hs Code.:

Synonyms:(3R)-1-azabicyclo[2.2.2]oct-3-yl (5-phenyl-1,3-oxazol-4-yl)carbamate hydrochloride

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Chemical Property of (3R)-1-azabicyclo[2.2.2]oct-3-yl (5-phenyl-1,3-oxazol-4-yl)carbamate hydrochloride

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Technology Process of (3R)-1-azabicyclo[2.2.2]oct-3-yl (5-phenyl-1,3-oxazol-4-yl)carbamate hydrochloride

There total 4 articles about (3R)-1-azabicyclo[2.2.2]oct-3-yl (5-phenyl-1,3-oxazol-4-yl)carbamate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₀H₆N₂O₂

: 25333-42-0
(R)-quinuclidin-3-ol

: 1047672-15-0
(3R)-1-azabicyclo[2.2.2]oct-3-yl (5-phenyl-1,3-oxazol-4-yl)carbamate hydrochloride

Guidance literature:: C₁₀H₆N₂O₂; (R)-quinuclidin-3-ol; In N,N-dimethyl-formamide; toluene; for 2h; Reflux;

With hydrogenchloride; In ethanol; ethyl acetate;
DOI:10.1016/j.bmc.2014.04.031

Reference yield:

: 99924-18-2
5-phenyl-1,3-oxazole-4-carboxylic acid

: 1047672-15-0
(3R)-1-azabicyclo[2.2.2]oct-3-yl (5-phenyl-1,3-oxazol-4-yl)carbamate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; diphenyl phosphoryl azide / toluene / 0.67 h / 20 °C

2: toluene / 1 h / 90 °C

3: toluene; N,N-dimethyl-formamide / 2 h / Reflux

With diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide; toluene; 2: |Curtius Rearrangement;
DOI:10.1016/j.bmc.2014.04.031

Reference yield:

: C₁₀H₆N₄O₂

: 1047672-15-0
(3R)-1-azabicyclo[2.2.2]oct-3-yl (5-phenyl-1,3-oxazol-4-yl)carbamate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 1 h / 90 °C

2: toluene; N,N-dimethyl-formamide / 2 h / Reflux

In N,N-dimethyl-formamide; toluene; 1: |Curtius Rearrangement;
DOI:10.1016/j.bmc.2014.04.031