(2-{(S)-5-Benzyl-3-[2-((S)-3-benzyl-5-methyl-2-oxo-imidazolidin-1-yl)-ethyl]-2-oxo-imidazolidin-1-yl}-2-oxo-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

Base Information

• Chemical Name: (2-{(S)-5-Benzyl-3-[2-((S)-3-benzyl-5-methyl-2-oxo-imidazolidin-1-yl)-ethyl]-2-oxo-imidazolidin-1-yl}-2-oxo-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester
• CAS No.: 181314-37-4
• Molecular Formula: C₄₀H₄₁N₅O₅
• Molecular Weight: 671.796
• Mol file: 181314-37-4.mol

Synonyms:(2-{(S)-5-Benzyl-3-[2-((S)-3-benzyl-5-methyl-2-oxo-imidazolidin-1-yl)-ethyl]-2-oxo-imidazolidin-1-yl}-2-oxo-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

Chemical Property of (2-{(S)-5-Benzyl-3-[2-((S)-3-benzyl-5-methyl-2-oxo-imidazolidin-1-yl)-ethyl]-2-oxo-imidazolidin-1-yl}-2-oxo-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-{(S)-5-Benzyl-3-[2-((S)-3-benzyl-5-methyl-2-oxo-imidazolidin-1-yl)-ethyl]-2-oxo-imidazolidin-1-yl}-2-oxo-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

There total 12 articles about (2-{(S)-5-Benzyl-3-[2-((S)-3-benzyl-5-methyl-2-oxo-imidazolidin-1-yl)-ethyl]-2-oxo-imidazolidin-1-yl}-2-oxo-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

9H-fluoren-9-ylmethyl (2-chloro-2-oxoethyl)carbamate (103321-49-9) + (S)-1-Benzyl-3-[2-((S)-4-benzyl-2-oxo-imidazolidin-1-yl)-ethyl]-4-methyl-imidazolidin-2-one (181314-36-3) → (2-{(S)-5-Benzyl-3-[2-((S)-3-benzyl-5-methyl-2-oxo-imidazolidin-1-yl)-ethyl]-2-oxo-imidazolidin-1-yl}-2-oxo-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester (181314-37-4)

Guidance literature:

With 2,6-di-tert-butyl-4-methylpyridine; In dichloromethane; at 25 ℃; for 4h;

DOI:10.1016/0040-4039(96)01101-X

Reference yield:

tert-butyl (S)-[1-(benzylamino)-1-oxopropan-2-yl]carbamate (51814-55-2,140866-04-2) → (2-{(S)-5-Benzyl-3-[2-((S)-3-benzyl-5-methyl-2-oxo-imidazolidin-1-yl)-ethyl]-2-oxo-imidazolidin-1-yl}-2-oxo-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester (181314-37-4)

Guidance literature:

Multi-step reaction with 11 steps

1: 98 percent / TFA / CH₂Cl₂ / 1 h / 25 °C

2: BH₃*THF / tetrahydrofuran / 22 h / Heating

3: CH₂Cl₂ / 16 h / 25 °C

4: 90 percent / 2,6-di-t-butyl-4-methyl pyridine / CH₂Cl₂ / 4 h / 25 °C

5: 60 percent / piperidine / CH₂Cl₂ / 1 h / 25 °C

6: BH₃*THF / tetrahydrofuran / 3 h / 60 °C

7: CH₂Cl₂ / 2.5 h / 25 °C

8: 100 percent / TFA / CH₂Cl₂ / 1 h / 25 °C

9: BH₃*THF / tetrahydrofuran / 22 h / Heating

10: CH₂Cl₂ / 16 h / 25 °C

11: 73 percent / 2,6-di-t-butyl-4-methylpyridine / CH₂Cl₂ / 4 h / 25 °C

With piperidine; 2,6-di-tert-butyl-4-methylpyridine; borane-THF; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/0040-4039(96)01101-X

Reference yield:

(S)-2-amino-N-benzylpropanamide (75040-72-1) → (2-{(S)-5-Benzyl-3-[2-((S)-3-benzyl-5-methyl-2-oxo-imidazolidin-1-yl)-ethyl]-2-oxo-imidazolidin-1-yl}-2-oxo-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester (181314-37-4)

Guidance literature:

Multi-step reaction with 10 steps

1: BH₃*THF / tetrahydrofuran / 22 h / Heating

2: CH₂Cl₂ / 16 h / 25 °C

3: 90 percent / 2,6-di-t-butyl-4-methyl pyridine / CH₂Cl₂ / 4 h / 25 °C

4: 60 percent / piperidine / CH₂Cl₂ / 1 h / 25 °C

5: BH₃*THF / tetrahydrofuran / 3 h / 60 °C

6: CH₂Cl₂ / 2.5 h / 25 °C

7: 100 percent / TFA / CH₂Cl₂ / 1 h / 25 °C

8: BH₃*THF / tetrahydrofuran / 22 h / Heating

9: CH₂Cl₂ / 16 h / 25 °C

10: 73 percent / 2,6-di-t-butyl-4-methylpyridine / CH₂Cl₂ / 4 h / 25 °C

With piperidine; 2,6-di-tert-butyl-4-methylpyridine; borane-THF; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/0040-4039(96)01101-X

upstream raw materials:

9H-fluoren-9-ylmethyl (2-chloro-2-oxoethyl)carbamate

(S)-1-Benzyl-3-[2-((S)-4-benzyl-2-oxo-imidazolidin-1-yl)-ethyl]-4-methyl-imidazolidin-2-one

tert-butyl (S)-[1-(benzylamino)-1-oxopropan-2-yl]carbamate

(S)-2-amino-N-benzylpropanamide

Downstream raw materials:

[(S)-1-(2-{(S)-5-Benzyl-3-[2-((S)-3-benzyl-5-methyl-2-oxo-imidazolidin-1-yl)-ethyl]-2-oxo-imidazolidin-1-yl}-ethylcarbamoyl)-propyl]-carbamic acid tert-butyl ester