(3R,6S)-1-Benzyl-3-[3-((2R,5S)-4-benzyl-6-ethoxy-5-isopropyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-propyl]-3-(3-chloro-propyl)-5-ethoxy-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one

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Chemical Name:(3R,6S)-1-Benzyl-3-[3-((2R,5S)-4-benzyl-6-ethoxy-5-isopropyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-propyl]-3-(3-chloro-propyl)-5-ethoxy-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one
CAS No.:618462-36-5
Molecular Formula:C₃₈H₅₃ClN₄O₄
Molecular Weight:665.316
Hs Code.:

(3R,6S)-1-Benzyl-3-[3-((2R,5S)-4-benzyl-6-ethoxy-5-isopropyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-propyl]-3-(3-chloro-propyl)-5-ethoxy-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one

Synonyms:(3R,6S)-1-Benzyl-3-[3-((2R,5S)-4-benzyl-6-ethoxy-5-isopropyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-propyl]-3-(3-chloro-propyl)-5-ethoxy-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one

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Chemical Property of (3R,6S)-1-Benzyl-3-[3-((2R,5S)-4-benzyl-6-ethoxy-5-isopropyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-propyl]-3-(3-chloro-propyl)-5-ethoxy-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one

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Technology Process of (3R,6S)-1-Benzyl-3-[3-((2R,5S)-4-benzyl-6-ethoxy-5-isopropyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-propyl]-3-(3-chloro-propyl)-5-ethoxy-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one

There total 2 articles about (3R,6S)-1-Benzyl-3-[3-((2R,5S)-4-benzyl-6-ethoxy-5-isopropyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-propyl]-3-(3-chloro-propyl)-5-ethoxy-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 6940-76-7
1-iodo-3-chloro-propane

: 433735-04-7
1-[(3'R,6'S)-1'-benzyl-5'-ethoxy-3',6'-dihydro-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-5''-ethoxy-3'',6''-dihydro-6''-isopropylpyrazin-3''-yl-2''-one]propane

: 618462-36-5
(3R,6S)-1-Benzyl-3-[3-((2R,5S)-4-benzyl-6-ethoxy-5-isopropyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-propyl]-3-(3-chloro-propyl)-5-ethoxy-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one

: C₄₁H₅₈Cl₂N₄O₄

Guidance literature:: 1-[(3'R,6'S)-1'-benzyl-5'-ethoxy-3',6'-dihydro-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-5''-ethoxy-3'',6''-dihydro-6''-isopropylpyrazin-3''-yl-2''-one]propane; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

1-iodo-3-chloro-propane; In tetrahydrofuran;
DOI:10.1016/S0957-4166(03)00541-X

Reference yield:

: 142-28-9
1,3-Dichloropropane

: 433735-04-7
1-[(3'R,6'S)-1'-benzyl-5'-ethoxy-3',6'-dihydro-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-5''-ethoxy-3'',6''-dihydro-6''-isopropylpyrazin-3''-yl-2''-one]propane

: 618462-36-5
(3R,6S)-1-Benzyl-3-[3-((2R,5S)-4-benzyl-6-ethoxy-5-isopropyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-propyl]-3-(3-chloro-propyl)-5-ethoxy-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one

Guidance literature:: 1-[(3'R,6'S)-1'-benzyl-5'-ethoxy-3',6'-dihydro-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-5''-ethoxy-3'',6''-dihydro-6''-isopropylpyrazin-3''-yl-2''-one]propane; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;

1,3-Dichloropropane; In tetrahydrofuran;
DOI:10.1016/S0957-4166(03)00541-X