(3S,8aR)-2-Benzyl-8a-[3-((2S,5S)-4-benzyl-6-ethoxy-5-isopropyl-2-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-propyl]-3-isopropyl-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

Base Information

Chemical Name:(3S,8aR)-2-Benzyl-8a-[3-((2S,5S)-4-benzyl-6-ethoxy-5-isopropyl-2-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-propyl]-3-isopropyl-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione
CAS No.:618462-47-8
Molecular Formula:C₃₇H₅₀N₄O₄
Molecular Weight:614.828
Hs Code.:

(3S,8aR)-2-Benzyl-8a-[3-((2S,5S)-4-benzyl-6-ethoxy-5-isopropyl-2-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-propyl]-3-isopropyl-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

Synonyms:(3S,8aR)-2-Benzyl-8a-[3-((2S,5S)-4-benzyl-6-ethoxy-5-isopropyl-2-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-propyl]-3-isopropyl-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

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Chemical Property of (3S,8aR)-2-Benzyl-8a-[3-((2S,5S)-4-benzyl-6-ethoxy-5-isopropyl-2-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-propyl]-3-isopropyl-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

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Technology Process of (3S,8aR)-2-Benzyl-8a-[3-((2S,5S)-4-benzyl-6-ethoxy-5-isopropyl-2-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-propyl]-3-isopropyl-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

There total 3 articles about (3S,8aR)-2-Benzyl-8a-[3-((2S,5S)-4-benzyl-6-ethoxy-5-isopropyl-2-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-propyl]-3-isopropyl-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 618462-37-6
(3S,8aR)-2-Benzyl-8a-[3-((2R,5S)-4-benzyl-6-ethoxy-5-isopropyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-propyl]-3-isopropyl-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

: 74-88-4
methyl iodide

: 618462-47-8
(3S,8aR)-2-Benzyl-8a-[3-((2S,5S)-4-benzyl-6-ethoxy-5-isopropyl-2-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-propyl]-3-isopropyl-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

Guidance literature:: (3S,8aR)-2-Benzyl-8a-[3-((2R,5S)-4-benzyl-6-ethoxy-5-isopropyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-propyl]-3-isopropyl-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

methyl iodide; In tetrahydrofuran;
DOI:10.1016/S0957-4166(03)00541-X

Reference yield:

: 433735-04-7
1-[(3'R,6'S)-1'-benzyl-5'-ethoxy-3',6'-dihydro-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-5''-ethoxy-3'',6''-dihydro-6''-isopropylpyrazin-3''-yl-2''-one]propane

: 618462-47-8
(3S,8aR)-2-Benzyl-8a-[3-((2S,5S)-4-benzyl-6-ethoxy-5-isopropyl-2-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-propyl]-3-isopropyl-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: LHMDS / tetrahydrofuran / 1 h / -78 °C

1.2: 80 percent / tetrahydrofuran

2.1: NaI / acetone / 36 h / Heating

3.1: LHMDS / tetrahydrofuran / 1 h / -78 °C

3.2: 90 percent / tetrahydrofuran

With sodium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; acetone; 2.1: Finkelstein reaction;
DOI:10.1016/S0957-4166(03)00541-X

Reference yield:

: 618462-36-5
(3R,6S)-1-Benzyl-3-[3-((2R,5S)-4-benzyl-6-ethoxy-5-isopropyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-propyl]-3-(3-chloro-propyl)-5-ethoxy-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one

: 618462-47-8
(3S,8aR)-2-Benzyl-8a-[3-((2S,5S)-4-benzyl-6-ethoxy-5-isopropyl-2-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-propyl]-3-isopropyl-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaI / acetone / 36 h / Heating

2.1: LHMDS / tetrahydrofuran / 1 h / -78 °C

2.2: 90 percent / tetrahydrofuran

With sodium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; acetone; 1.1: Finkelstein reaction;
DOI:10.1016/S0957-4166(03)00541-X