1-(Tert-butoxycarbonyl)-3-phenylpyrrolidine-2-carboxylic acid

Base Information

• Chemical Name: 1-(Tert-butoxycarbonyl)-3-phenylpyrrolidine-2-carboxylic acid
• CAS No.: 143979-44-6
• Molecular Formula: C16H21NO4
• Molecular Weight: 291.34
• European Community (EC) Number: 894-303-2
• DSSTox Substance ID: DTXSID70405725
• Mol file: 143979-44-6.mol

Synonyms:143979-44-6;1-(TERT-BUTOXYCARBONYL)-3-PHENYLPYRROLIDINE-2-CARBOXYLIC ACID;3-PHENYL-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER;1-[(2-methylpropan-2-yl)oxycarbonyl]-3-phenylpyrrolidine-2-carboxylic acid;1-[(tert-butoxy)carbonyl]-3-phenylpyrrolidine-2-carboxylic acid;1-(TERT-BUTOXYCARBONYL)-3-PHENYLPROLINE;210420-48-7;MFCD32068294;DL-BOC-cis-3-Phenyl-pyrrolidine-2-carboxylic acid;SCHEMBL830155;DTXSID70405725;LNVFMMJOXRYVKX-UHFFFAOYSA-N;3-Phenyl-Pyrrolidine-1,2-DicarboxylicAcid1-Tert-ButylEster;MFCD02682337;MFCD06738936;AKOS015901437;AB28219;AS-71139;SY322942;SY344190;CS-0147327;FT-0690746;1-(Boc)-3-phenylpyrrolidine-2-carboxylic acid;1-(tert-Butoxycarbonyl)-3-phenyl-D,L-proline;C72719;EN300-1071488;(2R,3S)-1-Boc-3-phenylpyrrolidine-2-carboxylic Acid;(2S,3R)-1-Boc-3-phenylpyrrolidine-2-carboxylic Acid;Z1505715396;1-(tert-Butoxycarbonyl)-3-phenyl-2-pyrrolidinecarboxylic acid;3-phenylpyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester;1-(TERT-BUTOXYCARBONYL)-3-PHENYLPYRROLIDINE-2-CARBOXYLICACID

Chemical Property of 1-(Tert-butoxycarbonyl)-3-phenylpyrrolidine-2-carboxylic acid

Chemical Property:

• Vapor Pressure: 1.43E-08mmHg at 25°C
• Refractive Index: 1.548
• Boiling Point: 441.5 °C at 760 mmHg
• PKA: 3.85±0.40(Predicted)
• Flash Point: 220.8 °C
• PSA: 66.84000
• Density: 1.196 g/cm³
• LogP: 2.80210
• Storage Temp.: 2-8°C
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 291.14705815
• Heavy Atom Count: 21
• Complexity: 396

Purity/Quality:

97% ^*data from raw suppliers

3-phenyl-pyrrolidine-1,2-dicarboxylicacid1-tert-butylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCC(C1C(=O)O)C2=CC=CC=C2

Technology Process of 1-(Tert-butoxycarbonyl)-3-phenylpyrrolidine-2-carboxylic acid

There total 5 articles about 1-(Tert-butoxycarbonyl)-3-phenylpyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + trans-3-phenylproline (3005-68-3) → 1-(tert-butoxycarbonyl)-3-phenylproline (143979-44-6,210420-48-7,149252-59-5)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 0.333333h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + C11H13NO2*ClH (1426559-89-8) → 1-(tert-butoxycarbonyl)-3-phenylproline (143979-44-6,210420-48-7,149252-59-5)

Guidance literature:

With tetramethyl ammoniumhydroxide; In acetonitrile; at 20 ℃; for 72h;

DOI:10.1002/chir.22101

Reference yield:

(E)-3-phenylpropenal (14371-10-9) → 1-(tert-butoxycarbonyl)-3-phenylproline (143979-44-6,210420-48-7,149252-59-5)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium ethanolate / ethanol / 10 °C / Inert atmosphere

2: triethylsilane; trifluoroacetic acid / chloroform / 4.17 h / 20 °C

3: acetic acid; hydrogenchloride / water / 12 h / Reflux

4: tetramethyl ammoniumhydroxide / acetonitrile / 72 h / 20 °C

With hydrogenchloride; triethylsilane; tetramethyl ammoniumhydroxide; sodium ethanolate; acetic acid; trifluoroacetic acid; In ethanol; chloroform; water; acetonitrile;

DOI:10.1002/chir.22101

upstream raw materials:

di-tert-butyl dicarbonate

trans-3-phenylproline

C₁₁H₁₃NO₂*ClH

(E)-3-phenylpropenal

Downstream raw materials:

(2R,3R)-1-tert-butyl 2-methyl 3-phenylpyrrolidine-1,2-dicarboxylate

(2S,3S)-3-phenyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

(2R,3R)-N-(tert-butoxycarbonyl)-β-phenylproline

(2S,3S)-1-(tert-butoxycarbonyl)-3-phenylpyrrolidine-2-carboxylic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 143979-44-6 3-PHENYL-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

Send

Send

Metric Ton KG G Pound L ML

Send

Send