3005-68-3Relevant academic research and scientific papers
PIPERIDINE AND PYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
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Page/Page column 36, (2008/06/13)
The present invention is directed to compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
A convenient synthetic route to macrocyclic cis-3-phenylproline derivatives as mimics of Sandostatin
Damour, Dominique,Doerflinger, Gilles,Pantel, Guy,Labaudinière, Richard,Leconte, Jean-Pierre,Sablé, Serge,Vuilhorgne, Marc,Mignani, Serge
, p. 189 - 192 (2007/10/03)
Enantiomerically pure 14- and 20-membered cyclic proline derivatives 2a- d were conveniently prepared from cis-3-phenylproline using macrolactonisation or macrolactamisation reactions.
