7,8,9,11-tetramethoxy-4,5-dihydrobenzo[6,7]cyclohepta[1,2,3-ij]isoquinolin-10-yl cyclohexanecarboxylate

Base Information

Chemical Name:7,8,9,11-tetramethoxy-4,5-dihydrobenzo[6,7]cyclohepta[1,2,3-ij]isoquinolin-10-yl cyclohexanecarboxylate
CAS No.:1380309-41-0
Molecular Formula:C₂₈H₃₁NO₆
Molecular Weight:477.557
Hs Code.:

Synonyms:7,8,9,11-tetramethoxy-4,5-dihydrobenzo[6,7]cyclohepta[1,2,3-ij]isoquinolin-10-yl cyclohexanecarboxylate

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Chemical Property of 7,8,9,11-tetramethoxy-4,5-dihydrobenzo[6,7]cyclohepta[1,2,3-ij]isoquinolin-10-yl cyclohexanecarboxylate

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Technology Process of 7,8,9,11-tetramethoxy-4,5-dihydrobenzo[6,7]cyclohepta[1,2,3-ij]isoquinolin-10-yl cyclohexanecarboxylate

There total 6 articles about 7,8,9,11-tetramethoxy-4,5-dihydrobenzo[6,7]cyclohepta[1,2,3-ij]isoquinolin-10-yl cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1380309-37-4
10-hydroxy-7,8,9,11-tetramethoxy-4,5-dihydrobenzo[6,7]cyclohepta[1,2,3-ij]isoquinoline

: 2719-27-9
cyclohexanylcarbonyl chloride

: 1380309-41-0
7,8,9,11-tetramethoxy-4,5-dihydrobenzo[6,7]cyclohepta[1,2,3-ij]isoquinolin-10-yl cyclohexanecarboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.04.007

Reference yield:

: 56771-99-4,61659-91-4
N-trifluoroacetyl-7-hydroxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-1,2,3,4-tetrahydroisoquinoline

: 1380309-41-0
7,8,9,11-tetramethoxy-4,5-dihydrobenzo[6,7]cyclohepta[1,2,3-ij]isoquinolin-10-yl cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: oxovanadium(V) fluoride; trifluoromethylsulfonic anhydride; trifluoroacetic acid / dichloromethane; ethyl acetate / 15.5 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With oxovanadium(V) fluoride; trifluoromethylsulfonic anhydride; triethylamine; trifluoroacetic acid; In dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2012.04.007

Reference yield:

: 67393-36-6
N-trifluoroacetyl-7-benzyloxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-1,2,3,4-tetrahydroisoquinoline

: 1380309-41-0
7,8,9,11-tetramethoxy-4,5-dihydrobenzo[6,7]cyclohepta[1,2,3-ij]isoquinolin-10-yl cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / Inert atmosphere

2: oxovanadium(V) fluoride; trifluoromethylsulfonic anhydride; trifluoroacetic acid / dichloromethane; ethyl acetate / 15.5 h / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With oxovanadium(V) fluoride; trifluoromethylsulfonic anhydride; palladium 10% on activated carbon; hydrogen; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2012.04.007