N-trifluoroacetyl-7-benzyloxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:N-trifluoroacetyl-7-benzyloxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:67393-36-6
Molecular Formula:C₃₀H₃₂F₃NO₆
Molecular Weight:559.582
Hs Code.:

Synonyms:N-trifluoroacetyl-7-benzyloxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of N-trifluoroacetyl-7-benzyloxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-1,2,3,4-tetrahydroisoquinoline

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Technology Process of N-trifluoroacetyl-7-benzyloxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-1,2,3,4-tetrahydroisoquinoline

There total 5 articles about N-trifluoroacetyl-7-benzyloxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7-benzyloxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-1,2,3,4-tetrahydroisoquinoline

: 407-25-0
trifluoroacetic anhydride

: 67393-36-6
N-trifluoroacetyl-7-benzyloxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.04.007

Reference yield:

: 25173-72-2
3-(3,4,5-trimethoxyphenyl)propanoic acid

: 67393-36-6
N-trifluoroacetyl-7-benzyloxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

2: trichlorophosphate / acetonitrile / 1 h / Inert atmosphere; Reflux

3: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 0 - 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 0 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2012.04.007

Reference yield:

: 20947-59-5
N-(4-benzyloxy-3-methoxyphenethyl)-3-(3',4',5'-trimethoxyphenyl)propionamide

: 67393-36-6
N-trifluoroacetyl-7-benzyloxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / acetonitrile / 1 h / Inert atmosphere; Reflux

2: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0 °C / Inert atmosphere

With sodium tetrahydroborate; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2012.04.007