3-Pyrrolidinecarboxylicacid,2-methyl-,methylester,(2S-cis)-(9CI)

Base Information

• Chemical Name: 3-Pyrrolidinecarboxylicacid,2-methyl-,methylester,(2S-cis)-(9CI)
• CAS No.: 143878-87-9
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.186
• Mol file: 143878-87-9.mol

Synonyms:3-Pyrrolidinecarboxylicacid,2-methyl-,methylester,(2S-cis)-(9CI)

Chemical Property of 3-Pyrrolidinecarboxylicacid,2-methyl-,methylester,(2S-cis)-(9CI)

Chemical Property:

• Boiling Point: 182.5±33.0 °C(Predicted)
• PKA: 9.85±0.10(Predicted)
• PSA: 38.33000
• Density: 1.005±0.06 g/cm3(Predicted)
• LogP: 0.48620

Purity/Quality:

97% ^*data from raw suppliers

(2S,3S)-Methyl2-methylpyrrolidine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyrrolidinecarboxylicacid,2-methyl-,methylester,(2S-cis)-(9CI)

There total 5 articles about 3-Pyrrolidinecarboxylicacid,2-methyl-,methylester,(2S-cis)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(2S,3S)-<1-(1(S)-phenylethyl)-2-methylpyrrolidin-3-yl>carboxylic acid methyl ester (143878-86-8) → methyl (2S,3S)-2-methylpyrrolidine-3-carboxylate (143878-87-9)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1016/S0040-4039(00)74247-X

Reference yield:

methyl 2-acetylcyclopropanecarboxylate (143955-12-8,178033-26-6) → methyl (2S,3S)-2-methylpyrrolidine-3-carboxylate (143878-87-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / toluene / Heating

2: 90 percent / H₂ / Raney-Ni / 750.06 Torr / Heating

3: 80 percent / H₂ / Pd-C (10percent)

With hydrogen; palladium on activated charcoal; nickel; In toluene;

DOI:10.1016/S0040-4039(00)74247-X

Reference yield:

1-(1(S)-phenylethyl)-2-methyl-4,5-dihydropyrrole-3-carboxylic acid methyl ester (143878-85-7) → methyl (2S,3S)-2-methylpyrrolidine-3-carboxylate (143878-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / H₂ / Raney-Ni / 750.06 Torr / Heating

2: 80 percent / H₂ / Pd-C (10percent)

With hydrogen; palladium on activated charcoal; nickel;

DOI:10.1016/S0040-4039(00)74247-X

upstream raw materials:

(2S,3S)-<1-(1(S)-phenylethyl)-2-methylpyrrolidin-3-yl>carboxylic acid methyl ester

methyl 2-acetylcyclopropanecarboxylate

1-(1(S)-phenylethyl)-2-methyl-4,5-dihydropyrrole-3-carboxylic acid methyl ester

acetoacetic acid methyl ester

Downstream raw materials:

(2S,3S)-1-[(tert-butoxy)carbonyl]-2-methylpyrrolidine-3-carboxylic acid