Methyl 4-acetamido-5-chloro-2-hydroxy-3-iodobenzoate

Base Information

Chemical Name:Methyl 4-acetamido-5-chloro-2-hydroxy-3-iodobenzoate
CAS No.:143878-24-4
Molecular Formula:C10H9 Cl I N O4
Molecular Weight:369.543
Hs Code.:2924299090
DSSTox Substance ID:DTXSID90452812
Wikidata:Q82273652
Mol file:143878-24-4.mol

Synonyms:143878-24-4;Methyl 4-acetamido-5-chloro-2-hydroxy-3-iodobenzoate;4-ACETYLAMINO-5-CHLORO-2-HYDROXY-3-IODOBENZOIC ACID METHYL ESTER;methyl 3-iodo-4-acetamido-5-chlorosalicylate;SCHEMBL5311964;DTXSID90452812;KHLJMCYDOCEJNR-UHFFFAOYSA-N;Benzoic acid, 4-(acetylamino)-5-chloro-2-hydroxy-3-iodo-, methyl ester;AS-78165;FT-0755205;D95454;Methyl 3-iodo-4-acetamido-5-chloro-salicylate;Methyl4-acetamido-5-chloro-2-hydroxy-3-iodobenzoate

Suppliers and Price of Methyl 4-acetamido-5-chloro-2-hydroxy-3-iodobenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Methyl4-acetamido-5-chloro-2-hydroxy-3-iodobenzoate 95+%
1g
$ 581.00

American Custom Chemicals Corporation
4-ACETYLAMINO-5-CHLORO-2-HYDROXY-3-IODOBENZOIC ACID METHYL ESTER 95.00%
5MG
$ 502.63

Aaron Chemicals
Benzoicacid,4-(acetylamino)-5-chloro-2-hydroxy-3-iodo-,methylester 95%
5g
$ 226.00

Total 7 raw suppliers

Chemical Property of Methyl 4-acetamido-5-chloro-2-hydroxy-3-iodobenzoate

Chemical Property:

PSA：79.12000
LogP:3.04470
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:368.92648
Heavy Atom Count:17
Complexity:315

Purity/Quality:

98%min ^*data from raw suppliers

Methyl4-acetamido-5-chloro-2-hydroxy-3-iodobenzoate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)NC1=C(C=C(C(=C1I)O)C(=O)OC)Cl

Technology Process of Methyl 4-acetamido-5-chloro-2-hydroxy-3-iodobenzoate

There total 5 articles about Methyl 4-acetamido-5-chloro-2-hydroxy-3-iodobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.8%

: 24190-77-0
methyl 4-acetylamino-5-chloro-2-hydroxybenzoate

: 143878-24-4
methyl 4-acetylamino-5-chloro-2-hydroxy-3-iodobenzoate

Guidance literature:: With sodium hydrogencarbonate; N,N,N-trimethylbenzenemethanaminium dichloroiodate; In methanol; dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 4093-28-1
methyl 4-acetamido-2-hydroxybenzoate

: 143878-24-4
methyl 4-acetylamino-5-chloro-2-hydroxy-3-iodobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / SO₂Cl₂ / CHCl₃ / 3 h / 25 °C

2: 77 percent / NaI, chloramine-T / dimethylformamide / 1 h / 10 °C

With sulfuryl dichloride; chloroamine-T; sodium iodide; In chloroform; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(96)00497-0

Reference yield:

: 4136-97-4
methyl 4-aminosalicylate

: 143878-24-4
methyl 4-acetylamino-5-chloro-2-hydroxy-3-iodobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent / pyridine / CHCl₃ / 2 h

2: 80 percent / SO₂Cl₂ / CHCl₃ / 3 h / 25 °C

3: 77 percent / NaI, chloramine-T / dimethylformamide / 1 h / 10 °C

With pyridine; sulfuryl dichloride; chloroamine-T; sodium iodide; In chloroform; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(96)00497-0