(+/-)-N-benzyloxycarbonyl-6,7-dihydroxy-5-dimethylaminomethyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: (+/-)-N-benzyloxycarbonyl-6,7-dihydroxy-5-dimethylaminomethyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 344746-45-8
• Molecular Formula: C₃₀H₃₆N₂O₇
• Molecular Weight: 536.625
• Mol file: 344746-45-8.mol

Synonyms:(+/-)-N-benzyloxycarbonyl-6,7-dihydroxy-5-dimethylaminomethyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property of (+/-)-N-benzyloxycarbonyl-6,7-dihydroxy-5-dimethylaminomethyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-N-benzyloxycarbonyl-6,7-dihydroxy-5-dimethylaminomethyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

There total 3 articles about (+/-)-N-benzyloxycarbonyl-6,7-dihydroxy-5-dimethylaminomethyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N,N-dimethyl(methylene)ammonium chloride (30354-18-8) + (+/-)-N-benzyloxycarbonyl-6,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline (80601-70-3) → (+/-)-N-benzyloxycarbonyl-6,7-dihydroxy-5-dimethylaminomethyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline (344746-45-8)

Guidance literature:

With triethylamine; In acetonitrile; at 0 ℃; for 1h;

DOI:10.1248/cpb.29.2816

Reference yield:

trimetoquinol (21650-42-0) → (+/-)-N-benzyloxycarbonyl-6,7-dihydroxy-5-dimethylaminomethyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline (344746-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / NaHCO₃ / CHCl₃; H₂O / 1 h / 5 °C / then 2 h room temperature

2: 87 percent / Et₃N / acetonitrile / 1 h / 0 °C

With sodium hydrogencarbonate; triethylamine; In chloroform; water; acetonitrile;

DOI:10.1248/cpb.29.2816

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → (+/-)-N-benzyloxycarbonyl-6,7-dihydroxy-5-dimethylaminomethyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline (344746-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / NaHCO₃ / CHCl₃; H₂O / 1 h / 5 °C / then 2 h room temperature

2: 87 percent / Et₃N / acetonitrile / 1 h / 0 °C

With sodium hydrogencarbonate; triethylamine; In chloroform; water; acetonitrile;

DOI:10.1248/cpb.29.2816

upstream raw materials:

N,N-dimethyl(methylene)ammonium chloride

(+/-)-N-benzyloxycarbonyl-6,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

trimetoquinol

benzyl chloroformate

Downstream raw materials:

(+/-)-N-benzyloxycarbonyl-6,7-dihydroxy-5-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline