4-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one 1,1-dioxide

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Chemical Name:4-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one 1,1-dioxide
CAS No.:1418201-61-2
Molecular Formula:C₁₉H₁₆FN₃O₃S
Molecular Weight:385.419
Hs Code.:

Synonyms:4-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one 1,1-dioxide

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Chemical Property of 4-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one 1,1-dioxide

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Technology Process of 4-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one 1,1-dioxide

There total 4 articles about 4-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1418201-59-8
4-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one

: 1418201-61-2
4-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one 1,1-dioxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 5325-20-2
2H-1,4-benzothiazin-3-one

: 1418201-61-2
4-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one 1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere

2: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 0.5 h / 150 °C / Microwave irradiation; Sealed tube

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;

Reference yield:

: 4-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one

: 1418201-61-2
4-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one 1,1-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 0.5 h / 150 °C / Microwave irradiation; Sealed tube

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; 1: |Suzuki Coupling;