4-Bromomethyl-3-fluorophenylboronic acid,pinacol

Base Information

• Chemical Name: 4-Bromomethyl-3-fluorophenylboronic acid,pinacol
• CAS No.: 1150271-74-1
• Molecular Formula: C13H17BBrFO2
• Molecular Weight: 314.9862832
• Hs Code.: 2934999090
• Mol file: 1150271-74-1.mol

Synonyms:4-Bromomethyl-3-fluorophenylboronic acid,pinacol;4-(Bromomethyl)-3-fluorobenzeneboronic acid, pinacol ester;2-[4-(Bromomethyl)-3-fluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;4-Bromomethyl-3-fluorophenylboronic acid, pinacol ester;4-Bromomethyl-3-fluorophenylboronic acid

Chemical Property of 4-Bromomethyl-3-fluorophenylboronic acid,pinacol

Chemical Property:

• PSA: 18.46000
• LogP: 3.01980
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Bromomethyl-3-fluorophenylboronicAcidPinacolEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Bromomethyl-3-fluorophenylboronic acid, pinacol ester

Technology Process of 4-Bromomethyl-3-fluorophenylboronic acid,pinacol

There total 1 articles about 4-Bromomethyl-3-fluorophenylboronic acid,pinacol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-(3-fluoro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (903895-56-7) → 2-(4-(bromomethyl)-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1150271-74-1)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In acetonitrile; at 90 ℃; for 4h;

DOI:10.1016/j.tetlet.2010.05.104

Reference yield: 82.0%

2-(4-(bromomethyl)-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1150271-74-1) → 2-(4-(azidomethyl)-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Guidance literature:

With sodium azide; In ethanol; at 20 ℃; for 24h;

DOI:10.1016/j.tetlet.2010.05.104

Reference yield:

2H-1,4-benzothiazin-3-one (5325-20-2) + 2-(4-(bromomethyl)-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1150271-74-1) → 4-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 3h; Inert atmosphere;

upstream raw materials:

2-(3-fluoro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Downstream raw materials:

4-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one

4-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one-1-oxide

4-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one 1,1-dioxide

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