4-[({5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridin-3-yl}carbonyl)amino]-N,N,N-trimethylbutan-1-aminium iodide

Base Information

Chemical Name:4-[({5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridin-3-yl}carbonyl)amino]-N,N,N-trimethylbutan-1-aminium iodide
CAS No.:1281969-48-9
Molecular Formula:C₃₁H₃₂F₃N₆O₂*I
Molecular Weight:704.534
Hs Code.:

4-[({5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridin-3-yl}carbonyl)amino]-N,N,N-trimethylbutan-1-aminium iodide

Synonyms:4-[({5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridin-3-yl}carbonyl)amino]-N,N,N-trimethylbutan-1-aminium iodide

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Chemical Property of 4-[({5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridin-3-yl}carbonyl)amino]-N,N,N-trimethylbutan-1-aminium iodide

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Technology Process of 4-[({5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridin-3-yl}carbonyl)amino]-N,N,N-trimethylbutan-1-aminium iodide

There total 3 articles about 4-[({5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridin-3-yl}carbonyl)amino]-N,N,N-trimethylbutan-1-aminium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1281969-49-0
5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-N-[4-(dimethylamino)butyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide

: 74-88-4
methyl iodide

: 1281969-48-9
4-[({5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridin-3-yl}carbonyl)amino]-N,N,N-trimethylbutan-1-aminium iodide

Guidance literature:: In acetonitrile; at 55 ℃;

Reference yield:

: 848140-72-7
ethyl 5-iodo-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxylate

: 1281969-48-9
4-[({5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridin-3-yl}carbonyl)amino]-N,N,N-trimethylbutan-1-aminium iodide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydrogenphosphate trihydrate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / N,N-dimethyl-formamide / 3 h / 55 °C

2: methanol / 0.67 h / 100 °C / Sealed; Microwave irradiation

3: acetonitrile / 55 °C

With potassium hydrogenphosphate trihydrate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1150620-53-3
4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-1H-pyrazol-1-yl]benzonitrile

: 1281969-48-9
4-[({5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridin-3-yl}carbonyl)amino]-N,N,N-trimethylbutan-1-aminium iodide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydrogenphosphate trihydrate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / N,N-dimethyl-formamide / 3 h / 55 °C

2: methanol / 0.67 h / 100 °C / Sealed; Microwave irradiation

3: acetonitrile / 55 °C

With potassium hydrogenphosphate trihydrate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In methanol; N,N-dimethyl-formamide; acetonitrile;