3-chloro-4-(8-ethyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)-N-hydroxybenzimidamide

Base Information

Chemical Name:3-chloro-4-(8-ethyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)-N-hydroxybenzimidamide
CAS No.:1428760-84-2
Molecular Formula:C₂₇H₂₉ClN₈O₂
Molecular Weight:533.033
Hs Code.:

Synonyms:3-chloro-4-(8-ethyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)-N-hydroxybenzimidamide

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Chemical Property of 3-chloro-4-(8-ethyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)-N-hydroxybenzimidamide

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Technology Process of 3-chloro-4-(8-ethyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)-N-hydroxybenzimidamide

There total 15 articles about 3-chloro-4-(8-ethyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)-N-hydroxybenzimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428760-83-1
3-chloro-4-(8-ethyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)benzonitrile

: 1428760-84-2
3-chloro-4-(8-ethyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)-N-hydroxybenzimidamide

Guidance literature:: With hydroxylamine hydrochloride; sodium carbonate; In ethanol; at 50 ℃; for 3h;

Reference yield:

: 100-00-5
4-chlorobenzonitrile

: 1428760-84-2
3-chloro-4-(8-ethyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)-N-hydroxybenzimidamide

Guidance literature:: Multi-step reaction with 5 steps

1: 140 °C

2: hydrazine hydrate / ethanol / 50 °C

3: 3 h / 120 °C

4: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 15 h / 70 °C / Inert atmosphere

5: sodium carbonate; hydroxylamine hydrochloride / ethanol / 3 h / 50 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydroxylamine hydrochloride; sodium carbonate; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 16155-03-6
1-methyl-4-(4-nitrophenyl)piperazine

: 1428760-84-2
3-chloro-4-(8-ethyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)-N-hydroxybenzimidamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / ethanol / 50 °C

2: 3 h / 120 °C

3: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 15 h / 70 °C / Inert atmosphere

4: sodium carbonate; hydroxylamine hydrochloride / ethanol / 3 h / 50 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydroxylamine hydrochloride; sodium carbonate; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;