[2-(2-amino-1-methyl-ethoxy)-4-fluoro-phenyl]-(6-bromo-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-amine

Base Information

Chemical Name:[2-(2-amino-1-methyl-ethoxy)-4-fluoro-phenyl]-(6-bromo-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-amine
CAS No.:1332720-90-7
Molecular Formula:C₁₆H₁₆BrFN₄OS
Molecular Weight:411.298
Hs Code.:

Synonyms:[2-(2-amino-1-methyl-ethoxy)-4-fluoro-phenyl]-(6-bromo-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-amine

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Chemical Property of [2-(2-amino-1-methyl-ethoxy)-4-fluoro-phenyl]-(6-bromo-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-amine

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Technology Process of [2-(2-amino-1-methyl-ethoxy)-4-fluoro-phenyl]-(6-bromo-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-amine

There total 3 articles about [2-(2-amino-1-methyl-ethoxy)-4-fluoro-phenyl]-(6-bromo-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332721-18-2
[2-(2-amino-5-fluoro-phenoxy)-propyl]-carbamic acid tert-butyl ester

: 19673-93-9
6-bromo-4-chloro-5-methylthieno[2,3-d]pyrimidine

: 1332720-90-7
[2-(2-amino-1-methyl-ethoxy)-4-fluoro-phenyl]-(6-bromo-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-amine

Guidance literature:: [2-(2-amino-5-fluoro-phenoxy)-propyl]-carbamic acid tert-butyl ester; 6-bromo-4-chloro-5-methylthieno[2,3-d]pyrimidine; With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 100 ℃; for 72h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With sodium hydroxide; In dichloromethane;

Reference yield:

: 446-36-6
5-fluoro-2-nitrophenol

: 1332720-90-7
[2-(2-amino-1-methyl-ethoxy)-4-fluoro-phenyl]-(6-bromo-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 72 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 2.5 h / 20 °C / 2250.23 Torr

3.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 72 h / 100 °C

3.2: 1 h / 20 °C

With di-tert-butyl-diazodicarboxylate; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol;

Reference yield:

: 1332721-17-1
[2-(5-fluoro-2-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester

: 1332720-90-7
[2-(2-amino-1-methyl-ethoxy)-4-fluoro-phenyl]-(6-bromo-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 2.5 h / 20 °C / 2250.23 Torr

2.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 72 h / 100 °C

2.2: 1 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol;