(3S,4R)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone

Base Information

Chemical Name:(3S,4R)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone
CAS No.:111874-32-9
Molecular Formula:C₂₁H₃₅NO₃Si
Molecular Weight:377.599
Hs Code.:

Synonyms:(3S,4R)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone

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Chemical Property of (3S,4R)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone

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Technology Process of (3S,4R)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone

There total 3 articles about (3S,4R)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 111865-81-7
(3S,4R)-3-<(R)-1-hydroxyethyl>-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone

: 18162-48-6
tert-butyldimethylsilyl chloride

: 111874-32-9
(3S,4R)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 14h; Ambient temperature;
DOI:10.1016/S0040-4020(01)81722-1

Reference yield:

: 111865-66-8
(3S,4R)-1-(di-p-anisylmethyl)-3-acetyl-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone

: 111874-32-9
(3S,4R)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 115 mg / KBH(s-Bu)3, KI / tetrahydrofuran / 1 h / 0 °C

2: 91 percent / CAN / H₂O; acetonitrile / 1.5 h / 0 °C

3: 99 percent / imidazole / dimethylformamide / 14 h / Ambient temperature

With 1H-imidazole; ammonium cerium(IV) nitrate; potassium tri-sec-butyl-borohydride; potassium iodide; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4020(01)81722-1

Reference yield:

: 111865-89-5
(3S,4R)-1-(di-p-anisylmethyl)-3-<(R)-1-hydroxyethyl>-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone

: 111874-32-9
(3S,4R)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / CAN / H₂O; acetonitrile / 1.5 h / 0 °C

2: 99 percent / imidazole / dimethylformamide / 14 h / Ambient temperature

With 1H-imidazole; ammonium cerium(IV) nitrate; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4020(01)81722-1