Technology Process of 5-Hydroxy-4-methylpicolinaldehyde
There total 7 articles about 5-Hydroxy-4-methylpicolinaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 55 percent / SeO2 / dioxane / 4 h / Heating
2: 91 percent / p-toluenesulfonic acid monohydrate / toluene / Heating
3: 92 percent / H2 / 10percent Pd/C / 20 h / 2585.7 Torr
4: 10percent aq. H2SO4, aq. NaNO2 / H2O / a.) 0 deg C, 15 min, b.) reflux, 30 min
With
selenium(IV) oxide; sulfuric acid; hydrogen; toluene-4-sulfonic acid; sodium nitrite;
palladium on activated charcoal;
In
1,4-dioxane; water; toluene;
DOI:10.1021/jm00098a011
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 18 percent / fuming sulfuric acid, potassium nitrate / 16 h / 100 - 120 °C
2: 55 percent / SeO2 / dioxane / 4 h / Heating
3: 91 percent / p-toluenesulfonic acid monohydrate / toluene / Heating
4: 92 percent / H2 / 10percent Pd/C / 20 h / 2585.7 Torr
5: 10percent aq. H2SO4, aq. NaNO2 / H2O / a.) 0 deg C, 15 min, b.) reflux, 30 min
With
selenium(IV) oxide; sulfuric acid; hydrogen; toluene-4-sulfonic acid; potassium nitrate; sodium nitrite;
palladium on activated charcoal;
In
1,4-dioxane; water; toluene;
DOI:10.1021/jm00098a011
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 91 percent / p-toluenesulfonic acid monohydrate / toluene / Heating
2: 92 percent / H2 / 10percent Pd/C / 20 h / 2585.7 Torr
3: 10percent aq. H2SO4, aq. NaNO2 / H2O / a.) 0 deg C, 15 min, b.) reflux, 30 min
With
sulfuric acid; hydrogen; toluene-4-sulfonic acid; sodium nitrite;
palladium on activated charcoal;
In
water; toluene;
DOI:10.1021/jm00098a011