1074-99-3

Basic information

• Product Name: 4,6-Dimethyl-3-nitropyridine
• Synonyms: 3-Nitro-4,6-lutidine;Pyridine, 2,4-diMethyl-5-nitro-;2,4-DiMethyl-5-nitropyridine 97%;5-Nitro-2,4-lutidine;2,4-DiMethyl-5-nitropyridine 97%, 4-DiMethyl-5-nitropyridine 97%;2,4-Dimethyl-5-nitropyridine97%;4,6-DIMETHYL-3-NITROPYRIDINE;2,4-DIMETHYL-5-NITROPYRIDINE
• CAS NO: 1074-99-3
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.15
• Product Categories: Heterocycles;Heterocyclic Compound;Pyridines;Heterocycle-Pyridine series
• Mol File: 1074-99-3.mol
• Article Data: 13

Chemical Properties

• Melting Point: 20.5 °C
• Boiling Point: 254.595 °C at 760 mmHg
• Flash Point: 107.775 °C
• Appearance: /
• Density: 1.198 g/cm³
• Vapor Pressure: 0.027mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 2.57±0.18(Predicted)
• CAS DataBase Reference: 4,6-Dimethyl-3-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-Dimethyl-3-nitropyridine(1074-99-3)
• EPA Substance Registry System: 4,6-Dimethyl-3-nitropyridine(1074-99-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 1074-99-3(Hazardous Substances Data)

Usage

General Description

4,6-Dimethyl-3-nitropyridine is a chemical compound with the molecular formula C7H8N2O2. It is a nitro-substituted pyridine with two methyl groups on the 4 and 6 positions of the pyridine ring. 4,6-Dimethyl-3-nitropyridine is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used in the production of various organic compounds and can act as a building block for the synthesis of more complex molecules. 4,6-Dimethyl-3-nitropyridine is a yellow crystalline solid that is considered to be potentially harmful if ingested, inhaled, or comes into contact with the skin, and appropriate safety precautions should be followed when handling this chemical.

InChI:InChI=1/C7H8N2O2/c1-5-3-6(2)8-4-7(5)9(10)11/h3-4H,1-2H3

Upstream product

• 23056-33-9 2-chloro-4-methyl-5-nitro-pyridine 
• 13061-96-6 dihydroxy-methyl-borane 
• 823-96-1 Trimethylboroxine 
• 108-47-4 2,4-lutidine 

Downstream Products

• 1193-71-1 5-amino-2,4-dimethylpyridine 
• 27063-92-9 5-bromo-2,4-dimethyl-pyridine 
• 800401-90-5 5-methyl-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid ethyl ester 
• 860410-54-4 5-methyl-3H-pyrazolo[3,4-c]pyridine 
• 143509-34-6 2,4-dimethyl-5-hydroxypyridine N-oxide 
• 143509-41-5 5-hydroxy-4-methylpyridine-2-carboxaldehyde 
• 213685-57-5 2-amino-3-hydroxy-4,6-dimethylpyridine 
• 108-47-4 2,4-lutidine 

Relevant articles and documents

Preparation of nitropyridines by nitration of pyridines with nitric acid

Preparation of nitropyridines by nitration of pyridines with nitric acid was discussed. Trifluoroacetic anhydride was chilled in an ice bath and the pyridine or substituted pyridines were slowly added and stirred at chilled conditions for 2 h. Relative amounts of the reactants were required for the nitration of pyridine were characterized by 1H and Nuclear magnetic resonance (NMR) spectroscopy and elemental analysis. It was observed that the yields of β-nitropyridines obtained using the standard protocol were generally higher than those obtained using N2O3.

FACTOR XI ACTIVATION INHIBITORS

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XI activation inhibitors.

PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE

Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.