4-ethoxycarbonyl-5-methyl-3-(2-fluoro-5-iodophenyl)isoxazole

Base Information

• Chemical Name: 4-ethoxycarbonyl-5-methyl-3-(2-fluoro-5-iodophenyl)isoxazole
• CAS No.: 334971-57-2
• Molecular Formula: C₁₃H₁₁FINO₃
• Molecular Weight: 375.138
• Mol file: 334971-57-2.mol

Synonyms:4-ethoxycarbonyl-5-methyl-3-(2-fluoro-5-iodophenyl)isoxazole

Chemical Property of 4-ethoxycarbonyl-5-methyl-3-(2-fluoro-5-iodophenyl)isoxazole

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-ethoxycarbonyl-5-methyl-3-(2-fluoro-5-iodophenyl)isoxazole

There total 1 articles about 4-ethoxycarbonyl-5-methyl-3-(2-fluoro-5-iodophenyl)isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-fluoro-5-iodobenzoyl chloride oxime (334971-56-1) + Ethyl 2-butynoate (4341-76-8) → 4-ethoxycarbonyl-5-methyl-3-(2-fluoro-5-iodophenyl)isoxazole (334971-57-2)

Guidance literature:

With triethylamine; In diethyl ether; at 0 - 20 ℃; for 1h; Nitrogen gasification;

Reference yield: 86.0%

4-ethoxycarbonyl-5-methyl-3-(2-fluoro-5-iodophenyl)isoxazole (334971-57-2) → 3-(2-fluoro-5-iodo-phenyl)-5-methyl-isoxazole-4-carboxylic acid (334971-58-3)

Guidance literature:

4-ethoxycarbonyl-5-methyl-3-(2-fluoro-5-iodophenyl)isoxazole; With sodium hydroxide; In ethanol; water; at 50 ℃; for 1h; Stirring;

With hydrogenchloride; In water; pH=2;

upstream raw materials:

2-fluoro-5-iodobenzoyl chloride oxime

Ethyl 2-butynoate

Downstream raw materials:

3-(2-fluoro-5-iodo-phenyl)-5-methyl-isoxazole-4-carboxylic acid