4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-3-methoxy-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide

Base Information

• Chemical Name: 4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-3-methoxy-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide
• CAS No.: 1346263-90-8
• Molecular Formula: C₃₂H₄₆N₆O₄
• Molecular Weight: 578.755

Synonyms:4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-3-methoxy-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide

Chemical Property of 4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-3-methoxy-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide

Chemical Property:

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Technology Process of 4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-3-methoxy-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide

There total 5 articles about 4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-3-methoxy-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-3-methoxybenzoic acid (1346263-94-2) + 4-[4-(2-methoxyphenyl)piperazin-1-yl]butylamine (21103-33-3) → 4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-3-methoxy-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide (1346263-90-8)

Guidance literature:

With 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1021/jm2009919

Reference yield:

4-hydroxy-3-methoxybenzoic acid methyl ester (3943-74-6) → 4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-3-methoxy-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide (1346263-90-8)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate; potassium iodide / acetonitrile / 20 h / Reflux

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / hexane; dichloromethane; water; tert-butyl alcohol / 16 h / 20 °C

3: potassium hydroxide / methanol / 2 h / 60 °C

4: 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

With copper(ll) sulfate pentahydrate; 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate; potassium carbonate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; potassium iodide; potassium hydroxide; In methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

DOI:10.1021/jm2009919

Reference yield:

1-chloro-4-pentyne (14267-92-6) → 4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-3-methoxy-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide (1346263-90-8)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate; potassium iodide / acetonitrile / 20 h / Reflux

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / hexane; dichloromethane; water; tert-butyl alcohol / 16 h / 20 °C

3: potassium hydroxide / methanol / 2 h / 60 °C

4: 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

With copper(ll) sulfate pentahydrate; 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate; potassium carbonate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; potassium iodide; potassium hydroxide; In methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

DOI:10.1021/jm2009919

upstream raw materials:

methyl 4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-3-methoxybenzoate

4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-3-methoxybenzoic acid

4-[4-(2-methoxyphenyl)piperazin-1-yl]butylamine

methyl 3-methoxy-4-(pent-4-yn-1-yloxy)benzoate

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