3-[4-cyclohexylamino-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-propionic acid methyl ester

Base Information

Chemical Name:3-[4-cyclohexylamino-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-propionic acid methyl ester
CAS No.:1246350-05-9
Molecular Formula:C₂₄H₃₀N₄O₃
Molecular Weight:422.527
Hs Code.:

Synonyms:3-[4-cyclohexylamino-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-propionic acid methyl ester

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Chemical Property of 3-[4-cyclohexylamino-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-propionic acid methyl ester

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Technology Process of 3-[4-cyclohexylamino-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-propionic acid methyl ester

There total 7 articles about 3-[4-cyclohexylamino-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1246350-04-8
(E)-3-[4-Cyclohexylamino-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-acrylic acid methyl ester

: 1246350-05-9
3-[4-cyclohexylamino-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-propionic acid methyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃;

Reference yield:

: 26452-80-2
2,4-dichloropyridine

: 1246350-05-9
3-[4-cyclohexylamino-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2.5 h / -78 °C

1.2: 1.5 h / -78 °C

2.1: hydrazine hydrate / 1,2-dimethoxyethane / 20 - 75 °C

3.1: iodine; potassium hydroxide / 1,4-dioxane / 4 h / 75 °C

4.1: potassium hydroxide / N,N-dimethyl-formamide / 2.5 h / 20 °C

5.1: butan-1-ol / 20 - 190 °C / Microwave irradiation

6.1: tetra-(n-butyl)ammonium iodide; triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 70 °C

7.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 20 °C

With n-butyllithium; hydrogen; iodine; tetra-(n-butyl)ammonium iodide; hydrazine hydrate; triethylamine; diisopropylamine; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; hexane; water; ethyl acetate; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 871836-51-0
4-chloro-1H-pyrazolo [4,3-c]pyridine

: 1246350-05-9
3-[4-cyclohexylamino-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: iodine; potassium hydroxide / 1,4-dioxane / 4 h / 75 °C

2: potassium hydroxide / N,N-dimethyl-formamide / 2.5 h / 20 °C

3: butan-1-ol / 20 - 190 °C / Microwave irradiation

4: tetra-(n-butyl)ammonium iodide; triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 70 °C

5: hydrogen / palladium 10% on activated carbon / ethyl acetate / 20 °C

With hydrogen; iodine; tetra-(n-butyl)ammonium iodide; triethylamine; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide; butan-1-ol;