Technology Process of (2R,3S)-3-(2-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)ethyl)oxirane-2-carbaldehyde
There total 10 articles about (2R,3S)-3-(2-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)ethyl)oxirane-2-carbaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: NaH / CH2Cl2; tetrahydrofuran
2: 86 percent / DIBAL-H / diethyl ether
3: t-BuOOH; 4 Angstroem molecular sieves / Ti(O-i-Pr)4; L-(+)-diethyl tartrate / CH2Cl2; decane / 18 h / -20 °C
4: oxalyl chloride; DMSO; Et3N / CH2Cl2 / 2 h
With
tert.-butylhydroperoxide; oxalyl dichloride; 4 A molecular sieve; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine;
titanium(IV) isopropylate; diethyl (2R,3R)-tartrate;
In
tetrahydrofuran; diethyl ether; decane; dichloromethane;
3: Sharpless epoxidation / 4: Swern oxidation;
DOI:10.1021/ja061918e
- Guidance literature:
-
Multi-step reaction with 2 steps
1: t-BuOOH; 4 Angstroem molecular sieves / Ti(O-i-Pr)4; L-(+)-diethyl tartrate / CH2Cl2; decane / 18 h / -20 °C
2: oxalyl chloride; DMSO; Et3N / CH2Cl2 / 2 h
With
tert.-butylhydroperoxide; oxalyl dichloride; 4 A molecular sieve; dimethyl sulfoxide; triethylamine;
titanium(IV) isopropylate; diethyl (2R,3R)-tartrate;
In
decane; dichloromethane;
1: Sharpless epoxidation / 2: Swern oxidation;
DOI:10.1021/ja061918e
