Technology Process of 7-Quinazolinecarboxylic acid, 6-amino-1,4-dihydro-5,8-dimethoxy-2-methyl-4-oxo-, methyl ester (9CI)
There total 8 articles about 7-Quinazolinecarboxylic acid, 6-amino-1,4-dihydro-5,8-dimethoxy-2-methyl-4-oxo-, methyl ester (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
methanol;
for 4h;
under 2585.7 Torr;
DOI:10.1021/jo00047a017
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 80 percent / 1 N aq. NaOH, 10percent aq. hydrogen peroxide / ethanol / 0.33 h / 40 °C
2: 81 percent / H2 / 5percent Pd on carbon / methanol / 3 h / 2585.7 Torr
3: 78 percent / acetic acid / 4.5 h / 40 °C
4: 78 percent / 10percent aq. sodium hydroxide / ethanol / 24 h / Heating
5: 69 percent / conc. sulfuric acid / 10 h / Heating
6: 76 percent / NO2BF4 / acetonitrile / 0.17 h / Ambient temperature
7: 92 percent / H2 / 5percent Pd/C / methanol / 4 h / 2585.7 Torr
With
sodium hydroxide; nitronium tetrafluoborate; sulfuric acid; hydrogen; dihydrogen peroxide;
palladium on activated charcoal;
In
methanol; ethanol; acetic acid; acetonitrile;
DOI:10.1021/jo00047a017
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 71 percent / acetic anhydride, 90percent nitric acid / 0.25 h / Ambient temperature
2: 80 percent / 1 N aq. NaOH, 10percent aq. hydrogen peroxide / ethanol / 0.33 h / 40 °C
3: 81 percent / H2 / 5percent Pd on carbon / methanol / 3 h / 2585.7 Torr
4: 78 percent / acetic acid / 4.5 h / 40 °C
5: 78 percent / 10percent aq. sodium hydroxide / ethanol / 24 h / Heating
6: 69 percent / conc. sulfuric acid / 10 h / Heating
7: 76 percent / NO2BF4 / acetonitrile / 0.17 h / Ambient temperature
8: 92 percent / H2 / 5percent Pd/C / methanol / 4 h / 2585.7 Torr
With
sodium hydroxide; nitronium tetrafluoborate; sulfuric acid; hydrogen; dihydrogen peroxide; nitric acid; acetic anhydride;
palladium on activated charcoal;
In
methanol; ethanol; acetic acid; acetonitrile;
DOI:10.1021/jo00047a017
