7-Quinazolinecarboxylic acid, 1,4-dihydro-5,8-dimethoxy-2-methyl-6-nitro-4-oxo-, methyl ester (9CI)

Base Information

Chemical Name:7-Quinazolinecarboxylic acid, 1,4-dihydro-5,8-dimethoxy-2-methyl-6-nitro-4-oxo-, methyl ester (9CI)
CAS No.:143430-44-8
Molecular Formula:C13H13 N3 O7
Molecular Weight:323.262
Hs Code.:
Mol file:143430-44-8.mol

Synonyms:7-Quinazolinecarboxylicacid, 1,4-dihydro-5,8-dimethoxy-2-methyl-6-nitro-4-oxo-, methyl ester (9CI)

Suppliers and Price of 7-Quinazolinecarboxylic acid, 1,4-dihydro-5,8-dimethoxy-2-methyl-6-nitro-4-oxo-, methyl ester (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-Quinazolinecarboxylic acid, 1,4-dihydro-5,8-dimethoxy-2-methyl-6-nitro-4-oxo-, methyl ester (9CI)

Chemical Property:

Boiling Point:546.4±60.0 °C(Predicted)
PKA:-3.13±0.20(Predicted)
PSA：136.33000
Density:1.53±0.1 g/cm3(Predicted)
LogP:1.46670

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 7-Quinazolinecarboxylic acid, 1,4-dihydro-5,8-dimethoxy-2-methyl-6-nitro-4-oxo-, methyl ester (9CI)

There total 8 articles about 7-Quinazolinecarboxylic acid, 1,4-dihydro-5,8-dimethoxy-2-methyl-6-nitro-4-oxo-, methyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 143430-43-7
7-(methoxycarbonyl)-5,8-dimethoxy-2-methylquinazolin-4(3H)-one

: 143430-44-8
7-(methoxycarbonyl)-5,8-dimethoxy-2-methyl-6-nitroquinazolin-4(3H)-one

Guidance literature:: With nitronium tetrafluoborate; In acetonitrile; for 0.166667h; Ambient temperature;
DOI:10.1021/jo00047a017

Reference yield:

: NO₂ BF₄

: 143430-43-7
7-(methoxycarbonyl)-5,8-dimethoxy-2-methylquinazolin-4(3H)-one

: 143430-44-8
7-(methoxycarbonyl)-5,8-dimethoxy-2-methyl-6-nitroquinazolin-4(3H)-one

Guidance literature:: In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; acetonitrile;

Reference yield:

: 5628-41-1
3,6-dicyano-1,4-dimethoxy-2-nitrobenzene

: 143430-44-8
7-(methoxycarbonyl)-5,8-dimethoxy-2-methyl-6-nitroquinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / 1 N aq. NaOH, 10percent aq. hydrogen peroxide / ethanol / 0.33 h / 40 °C

2: 81 percent / H₂ / 5percent Pd on carbon / methanol / 3 h / 2585.7 Torr

3: 78 percent / acetic acid / 4.5 h / 40 °C

4: 78 percent / 10percent aq. sodium hydroxide / ethanol / 24 h / Heating

5: 69 percent / conc. sulfuric acid / 10 h / Heating

6: 76 percent / NO₂BF₄ / acetonitrile / 0.17 h / Ambient temperature

With sodium hydroxide; nitronium tetrafluoborate; sulfuric acid; hydrogen; dihydrogen peroxide; palladium on activated charcoal; In methanol; ethanol; acetic acid; acetonitrile;
DOI:10.1021/jo00047a017