methyl 2-((2S)-1-(4-((2'-fluoro-5'-methoxy-2-methylbiphenyl-4-yl)methoxy)phenyl)pyrrolidin-2-yl)acetate

Base Information

Chemical Name:methyl 2-((2S)-1-(4-((2'-fluoro-5'-methoxy-2-methylbiphenyl-4-yl)methoxy)phenyl)pyrrolidin-2-yl)acetate
CAS No.:1283146-89-3
Molecular Formula:C₂₈H₃₀FNO₄
Molecular Weight:463.549
Hs Code.:

Synonyms:methyl 2-((2S)-1-(4-((2'-fluoro-5'-methoxy-2-methylbiphenyl-4-yl)methoxy)phenyl)pyrrolidin-2-yl)acetate

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Chemical Property of methyl 2-((2S)-1-(4-((2'-fluoro-5'-methoxy-2-methylbiphenyl-4-yl)methoxy)phenyl)pyrrolidin-2-yl)acetate

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Technology Process of methyl 2-((2S)-1-(4-((2'-fluoro-5'-methoxy-2-methylbiphenyl-4-yl)methoxy)phenyl)pyrrolidin-2-yl)acetate

There total 10 articles about methyl 2-((2S)-1-(4-((2'-fluoro-5'-methoxy-2-methylbiphenyl-4-yl)methoxy)phenyl)pyrrolidin-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1283146-88-2
(S)-methyl 2-(1-(4-(4-bromo-3-methylbenzyloxy)phenyl)pyrrolidin-2-yl)acetate

: 406482-19-7
2-fluoro-5-methoxyphenylboronic acid

: 1283146-89-3
methyl 2-((2S)-1-(4-((2'-fluoro-5'-methoxy-2-methylbiphenyl-4-yl)methoxy)phenyl)pyrrolidin-2-yl)acetate

Guidance literature:: With sodium carbonate; ammonium chloride; bis-triphenylphosphine-palladium(II) chloride; In methanol; water; toluene; at 95 ℃; for 5h; Inert atmosphere;

Reference yield:

: 149104-89-2
4-bromo-3-methylbenzylalcohol

: 1283146-89-3
methyl 2-((2S)-1-(4-((2'-fluoro-5'-methoxy-2-methylbiphenyl-4-yl)methoxy)phenyl)pyrrolidin-2-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: carbon tetrabromide; triphenylphosphine / dichloromethane / 22 h / 20 °C

2: caesium carbonate / acetonitrile / 2 h / 50 °C

3: sodium carbonate; ammonium chloride / bis-triphenylphosphine-palladium(II) chloride / methanol; water; toluene / 5 h / 95 °C / Inert atmosphere

With carbon tetrabromide; sodium carbonate; ammonium chloride; caesium carbonate; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; In methanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 19578-68-8
4-(4-benzyloxyphenyl) iodide

: 1283146-89-3
methyl 2-((2S)-1-(4-((2'-fluoro-5'-methoxy-2-methylbiphenyl-4-yl)methoxy)phenyl)pyrrolidin-2-yl)acetate

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydroxide / copper(l) iodide / isopropyl alcohol / 90 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1 h / 0 °C

3: dimethyl sulfoxide / 4 h / 50 °C

4: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

5: hydrogenchloride / methanol; dichloromethane / 0 - 20 °C

6: caesium carbonate / acetonitrile / 2 h / 50 °C

7: sodium carbonate; ammonium chloride / bis-triphenylphosphine-palladium(II) chloride / methanol; water; toluene / 5 h / 95 °C / Inert atmosphere

With hydrogenchloride; hydrogen; sodium carbonate; ammonium chloride; caesium carbonate; triethylamine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol; toluene; acetonitrile;