149104-89-2

Basic information

• Product Name: (4-BROMO-3-METHYLPHENYL)METHANOL
• Synonyms: (4-BROMO-3-METHYLPHENYL)METHANOL;4-Bromo-3-methylbenzyl alcohol;4-Bromo-3-methylbenzylalcohol,tech;4-Bromo-3-methylbenzyl alcohol≥ 97% (GC)
• CAS NO: 149104-89-2
• Molecular Formula: C₈H₉BrO
• Molecular Weight: 201.07
• Mol File: 149104-89-2.mol
• Article Data: 32

Chemical Properties

• Melting Point: 31-32℃
• Boiling Point: 283℃
• Flash Point: 125℃
• Appearance: /
• Density: 1.481
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: 2-8°C
• PKA: 14.16±0.10(Predicted)
• CAS DataBase Reference: (4-BROMO-3-METHYLPHENYL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (4-BROMO-3-METHYLPHENYL)METHANOL(149104-89-2)
• EPA Substance Registry System: (4-BROMO-3-METHYLPHENYL)METHANOL(149104-89-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 149104-89-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H9BrO/c1-6-4-7(5-10)2-3-8(6)9/h2-4,10H,5H2,1H3

Upstream product

• 148547-19-7 4-Bromo-3-methylbenzoic acid methyl ester 
• 78775-11-8 3-methyl-4-bromobenzaldehyde 
• 7697-28-1 4-bromo-3-methylbenzoic acid 
• 160313-69-9 ethyl 3-methyl-4-bromobenzoate 

Downstream Products

• 530144-93-5 1-bromo-4-[(methoxymethoxy)methyl]-2-methylbenzene 
• 591775-18-7 3-(4-hydroxymethyl-2-methyl-phenyl)-acrylic acid methyl ester 
• 160504-66-5 2-((4-bromo-3-methylbenzyl)oxy)tetrahydro-2H-pyran 
• 1349734-27-5 tert-butyl N-[5-bromo-3-[5-[4-(bromomethyl)-2-methylphenyl]-1,3,4-oxadiazol-2-yl]pyrazin-2-yl]-N-tert-butoxycarbonylcarbamate 
• 1349734-28-6 tert-butyl N-[3-[5-[4-(bromomethyl)-2-methylphenyl]-1,3,4-oxadiazol-2-yl]-5-(1-isopropyl-6-oxo-3-pyridyl)pyrazin-2-yl]-N-tert-butoxycarbonylcarbamate 
• 215800-25-2 2-(4-bromo-3-methyl-phenyl)acetonitrile 
• 786625-94-3 C₉H₁₂BrN 
• 25978-69-2 4-cyano-3-methylbenzyl methanesulfonate 
• 1453500-06-5 5-benzyloxy-2-[2-(4-bromomethyl-2-methyl-phenyl)-2-oxo-ethyl]-2H-pyridazin-3-one 
• 1453500-23-6 1-[2-(4-bromomethyl-2-methyl-phenyl)-2-oxo-ethyl]-4-(5-methoxy-pyridin-2-ylmethoxy)-1H-pyridin-2-one 
• 1453500-00-9 1-[2-(4-bromomethyl-2-methyl-phenyl)-2-oxo-ethyl]-4-(5-fluoro-pyridin-2-ylmethoxy)-1H-pyridin-2-one 
• 1453500-04-3 1-[2-(4-bromomethyl-2-methyl-phenyl)-2-oxo-ethyl]-4-(5-bromo-pyridin-2-ylmethoxy)-1H-pyridin-2-one 

Relevant articles and documents

ION CHANNEL MODULATORS

The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

STAT DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Small molecule compound

The invention provides a small molecular compound, The small molecular compound is characterized by having a structure as shown in the following molecular general formula, wherein X1 and X2 are selected from carbon or nitrogen, G1 is a carbon ring or a heterocyclic ring with aromaticity, any one or more hydrogen atoms on the G1 ring are substituted by R1, wherein R1 is selected from nitrogen-containing groups. The small molecule compound can be used as an efficient and specific JAK kinase inhibitor, especially a Tyk2 inhibitor, and/or a JAK1 inhibitor, and/or a JAK1/Tyk2 dual inhibitor, or a Tyk2/JAK1 dual inhibitor or a Tyk2/Jak2 dual inhibitor.