(1R,2S)-2-Methyl-1-((R)-1-phenyl-ethylamino)-cyclohexanecarboxylic acid amide

Base Information

• Chemical Name: (1R,2S)-2-Methyl-1-((R)-1-phenyl-ethylamino)-cyclohexanecarboxylic acid amide
• CAS No.: 184035-09-4
• Molecular Formula: C₁₆H₂₄N₂O
• Molecular Weight: 260.379
• Mol file: 184035-09-4.mol

Synonyms:(1R,2S)-2-Methyl-1-((R)-1-phenyl-ethylamino)-cyclohexanecarboxylic acid amide

Chemical Property of (1R,2S)-2-Methyl-1-((R)-1-phenyl-ethylamino)-cyclohexanecarboxylic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S)-2-Methyl-1-((R)-1-phenyl-ethylamino)-cyclohexanecarboxylic acid amide

There total 4 articles about (1R,2S)-2-Methyl-1-((R)-1-phenyl-ethylamino)-cyclohexanecarboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-1-phenyl-ethyl-amine (3886-69-9) → (1R,2S)-2-Methyl-1-((R)-1-phenyl-ethylamino)-cyclohexanecarboxylic acid amide (184035-09-4)

Guidance literature:

Multi-step reaction with 3 steps

1: p-TsOH / toluene / 6 h / Heating

2: methanol / 3 h / 0 °C

3: conc. H₂SO₄ / hexane / 102 h

With sulfuric acid; toluene-4-sulfonic acid; In methanol; hexane; toluene;

DOI:10.1002/jlac.199619961126

Reference yield:

E/Z-<2(RS)>-2-Methyl-N-(R-α-methylbenzyl)-cyclohexaneimine (828291-16-3) → (1R,2S)-2-Methyl-1-((R)-1-phenyl-ethylamino)-cyclohexanecarboxylic acid amide (184035-09-4)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 3 h / 0 °C

2: conc. H₂SO₄ / hexane / 102 h

With sulfuric acid; In methanol; hexane;

DOI:10.1002/jlac.199619961126

Reference yield:

2-Methylcyclohexanone (583-60-8) → (1R,2S)-2-Methyl-1-((R)-1-phenyl-ethylamino)-cyclohexanecarboxylic acid amide (184035-09-4)

Guidance literature:

Multi-step reaction with 3 steps

1: p-TsOH / toluene / 6 h / Heating

2: methanol / 3 h / 0 °C

3: conc. H₂SO₄ / hexane / 102 h

With sulfuric acid; toluene-4-sulfonic acid; In methanol; hexane; toluene;

DOI:10.1002/jlac.199619961126

upstream raw materials:

(R)-1-phenyl-ethyl-amine

E/Z-<2(RS)>-2-Methyl-N-(R-α-methylbenzyl)-cyclohexaneimine

2-Methylcyclohexanone

Downstream raw materials:

(1R,2S)-1-Amino-2-methyl-cyclohexanecarboxylic acid amide