(4-(2-(3-(1H-benzo[d]imidazol-2-yl)propylamino)ethyl)piperazin-1-yl)(3,5-dichlorophenyl)methanone

Base Information

Chemical Name:(4-(2-(3-(1H-benzo[d]imidazol-2-yl)propylamino)ethyl)piperazin-1-yl)(3,5-dichlorophenyl)methanone
CAS No.:1355016-52-2
Molecular Formula:C₂₃H₂₇Cl₂N₅O
Molecular Weight:460.406
Hs Code.:

Synonyms:(4-(2-(3-(1H-benzo[d]imidazol-2-yl)propylamino)ethyl)piperazin-1-yl)(3,5-dichlorophenyl)methanone

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Chemical Property of (4-(2-(3-(1H-benzo[d]imidazol-2-yl)propylamino)ethyl)piperazin-1-yl)(3,5-dichlorophenyl)methanone

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Technology Process of (4-(2-(3-(1H-benzo[d]imidazol-2-yl)propylamino)ethyl)piperazin-1-yl)(3,5-dichlorophenyl)methanone

There total 7 articles about (4-(2-(3-(1H-benzo[d]imidazol-2-yl)propylamino)ethyl)piperazin-1-yl)(3,5-dichlorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1355016-67-9
tert-butyl 2-(3-(2-(4-(3,5-dichlorobenzoyl)piperazin-1-yl)ethylamino)propyl)-1H-benzo[d]imidazole-1-carboxylate

: 1355016-52-2
(4-(2-(3-(1H-benzo[d]imidazol-2-yl)propylamino)ethyl)piperazin-1-yl)(3,5-dichlorophenyl)methanone

Guidance literature:: tert-butyl 2-(3-(2-(4-(3,5-dichlorobenzoyl)piperazin-1-yl)ethylamino)propyl)-1H-benzo[d]imidazole-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 5h;

With sodium hydrogencarbonate; In dichloromethane; Saturated solution;
DOI:10.1016/j.bmc.2011.11.005

Reference yield:

: 1355016-60-2
2-(2-(4-(3,5-dichlorobenzoyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione

: 1355016-52-2
(4-(2-(3-(1H-benzo[d]imidazol-2-yl)propylamino)ethyl)piperazin-1-yl)(3,5-dichlorophenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / ethanol / 2 h / 60 °C

2.1: methanol / 2 h

3.1: sodium tris(acetoxy)borohydride / methanol / 6 h

4.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

4.2: Saturated solution

With sodium tris(acetoxy)borohydride; hydrazine hydrate; trifluoroacetic acid; In methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmc.2011.11.005

Reference yield:

: 1355016-62-4
(4-(2-aminoethyl)piperazin-1-yl)(3,5-dichlorophenyl)methanone

: 1355016-52-2
(4-(2-(3-(1H-benzo[d]imidazol-2-yl)propylamino)ethyl)piperazin-1-yl)(3,5-dichlorophenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 2 h

2.1: sodium tris(acetoxy)borohydride / methanol / 6 h

3.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

3.2: Saturated solution

With sodium tris(acetoxy)borohydride; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2011.11.005